Laboratory：Laboratory of Structural Biology

Research direction: Studies on the regulatory mechanism of ion channels and transporters

Paper：

1、Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L. Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron. 2022 Mar 16;110(6):1023-1035.e5. doi: 10.1016/j.neuron.2021.12.023. Epub 2022 Jan 19. PMID: 35051376.

2、Guo W, Wang M, Chen L. A co-expression vector for baculovirus-mediated protein expression in mammalian cells. Biochem Biophys Res Commun. 2022 Feb 26;594:69-73. doi: 10.1016/j.bbrc.2022.01.056. Epub 2022 Jan 19. PMID: 35074588.

3、Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L. Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife. 2021 Mar 8;10:e63429. doi: 10.7554/eLife.63429. PMID: 33683200; PMCID: PMC7987348.

4、Guo W, Chen L. Recent progress in structural studies on canonical TRP ion channels. Cell Calcium. 2019 Nov;83:102075. doi: 10.1016/j.ceca.2019.102075. Epub 2019 Aug 28. PMID: 31491644.

5、Tang Q, Guo W, Zheng L, Wu JX, Liu M, Zhou X, Zhang X, Chen L. Structure of the receptor-activated human TRPC6 and TRPC3 ion channels. Cell Res. 2018 Jul;28(7):746-755. doi: 10.1038/s41422-018-0038-2. Epub 2018 Apr 26. PMID: 29700422; PMCID: PMC6028632.