Ph.D.

Biography

Dr. Xiong is a principal investigator in College of Future Technology, Peking University. His research interests focus on understanding molecular and cellular basis of heart regeneration and their translational studies on heart disease. He is well known for his contributions to determining the first genetic interval of zebrafish cloche mutant, establishing the very first CRISPR-induced zebrafish and rat mutants, and discovering the first small-molecule cocktail enabling rat heart regeneration. He has published over 70 peer-reviewed papers including journals Cell Stem Cell, Nature Communications, Cell Research, Circulation Research, Development, etc. He currently serve as expert member of National Key R&D Program on Developmental Reprogramming and Metabolic Regulation, vice Editor-in-Chief of the journal Cell Regeneration, and co-organizer for the “International Society of Regenerative Biology Webinars” and the biennial “China Organ Regeneration Conferences”.

Courses

n Cardiac Regenerative Medicine (Graduate Students and Undergraduate Students, 2 credits)

n Heart Development and Regenerative Biology (Graduate Students, 2 credits)

Education

n BS 1985 Biology, Jiangxi University (Nanchang University)

n Ph. D.  1991 Cell Biology, Institute of Zoology, Chinese Academy of Sciences (Supervisor: Prof. Shusen Liu)

Experience

n 1994. 3 – 1999.2  Postdoctoral Fellow, Department of Molecular Biology, Mount Sinai School of Medicine, New York, USA (Advisor: Prof. Heidi Stuhlmann)

n 1999. 3 – 2005.8  Research Associate/Instructor, Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, USA (Advisor: Prof. Mark C. Fishman)  

n 2005. 9 – 2008.10  Assistant Professor and Lab Head, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

n 2008. 10 – 2021.3  Principal Investigator, Institute of Molecular Medicine, Peking University, Beijing, China

n 2021. 4 – present Principal Investigator, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China

Current Funding Projects:

n 2018.1-2022.12 Principal Investigator, National Natural Science Foundation of China (No. 31730061)

Title: Cerebral blood vessel development and underlying mechanisms (RMB 3,110,000)

n 2020. 12 – 2023.11 Principal Investigator, Outstanding Translational Research Award, Nanjing, China

Title: Translational studies on heart regeneration (RMB 5,000,000)

Representative publications:

1. Wang C, Faloon PW, Tan Z, Lv Z, Zhang P, Ge Y, *Deng H, and *Xiong JW. (2007). Mouse Lycat controls the development of hematopoietic and endothelial lineages during in vitro ES cell differentiation. Blood, 110: 3601-3609.

2. *Xiong JW, Yu Q, Zhang J, and Mably JD. (2008). An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish. Circulation Research, 102:1057-1064.

3. Wang X, Yu Q, Wu Q, Bu Y, Chang NN, Yan S, Zhu X, and *Xiong JW. (2013). Genetic interaction between pku300 and fbn2b controls endocardial cell proliferation and valve development in zebrafish. Journal of Cell Science, 126:1381-91.

4. ^#Chang N, ^#Sun C, Gao L, Zhu D, Xu X, Zhu X, *Xiong JW, and *Xi J (2013). Genome Editing with RNA-guided Cas9 Nuclease in Zebrafish Embryos. Cell Research, 23:465-72.

5. *Hu XL, Chang N, Wang X, Zhou F, Zhou X, Zhu X and *Xiong JW (2013). Heritable gene targeting with gRNA/Cas9 in rats. Cell Research, 23: 1322-1325.

6. ^#Han P, ^#Zhou XH, Chang N, Xiao CL, Yan S, Ren H, Yang XZ, Zhang ML, Wu Q, Tang Y, Diao JP, Zhu X, Zhang CM, Li CY, *Cheng H, and *Xiong JW (2014). Hydrogen Peroxide Primes Heart Regeneration with a Derepression Mechanism. Cell Research, 24: 1091-1107.

7. Xiao CL^#, Gao L^#, Hou Y, Xu C, Chang N, Wang F, Hu K, He A, Luo, Y, Wang J, Peng JR, Tang F, Zhu X*, and Xiong JW*. (2016). Chromatin Remodeling Factor Brg1 Regulates Myocardial Proliferation and Regeneration in Zebrafish. Nature Communications, 7, 13787.

8. Yang R, Zhang Y, Huang D, Luo X, Zhang LR, Zhu X, Zhang XL, Liu Z*, Han J*, and Xiong JW*. (2017). Miconazole Protects Blood Vessels from MMP9-Dependent Rupture and Hemorrhage. Disease Models & Mechanisms, 10(3):337-348.

9. Pang MJ^#, Bai L^#, Zong W^#, Wang X, Bu Y, Xiong C, Zheng J, Li J, Gao W, Feng Z, Chen LY, Zhang J, Cheng H, Zhu X*, and Xiong JW*. (2020). Light-Sheet Fluorescence Imaging Charts the Gastrula Origin of Vascular Endothelial Cells in Early Zebrafish Embryos. Cell Discovery, 6:74.

10. Du J^#, Zheng L^#, Gao P, Yang H, Yang WJ, Guo F, Liang R, Feng M, Wang Z, Zhang Z, Bai L, Bu Y, Xing S, Zheng W, Wang X, Quan L, Hu XL, Wu H, Chen Z, Chen, LY, Wei K, Zhang Z, Zhu X, Zhang XL, Tu Q, Zhao SM*, Lei X*, and Xiong JW*. (2022). A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Cell Stem Cell, 29:545-558.