Peking University Chair Professor

Dean of the College of Future Technology

Associate editor of New England Journal of Medicine

Dr. Xiao’s research has been focused on cardiovascular and metabolic diseases, with a major emphasis on a translational approach to take bench discoveries into clinically relevant situations. She has over 160 publications in peer-reviewed journals, such as  Nature ,  Nature Medicine ,  Nature Cell Biology ,  Molecular Cell , and  Circulation , with over 11,000 citations. Dr. Xiao serves as a council member of the International Society of Heart Research (ISHR) and the American Society for Clinical Investigation (ASCI), and as an Associate Editor of the  New England Journal of Medicine and on the editorial board of several other scientific journals.

Teaching Activities

Advanced molecular medicine

Physiology

Pathophysiology of cardiometabolic diseases

Cardiovascular Pharmacology

Education

1988 - 1989 Postdoctoral Fellow, Medical School, Univ. of Puerto Rico.

1990 - 1991 Postdoctoral Fellow, Laboratory of Cardiovascular Science (LCS), National Institute on Aging (NIA), NIH.

1992 - 1996 Staff Scientist, LCS, NIA, NIH.

1996 - 2003 Investigator, LCS, NIA, NIH (Unit Head)

2003 - 2010 Senior Investigator with tenure, LCS, NIA, NIH (with tenure, Seciton Head)

Research Grants

2018-2023 Functional study of protein glycosylation in metabolic diseases and cardiovascular complications, 2018YFA0507603, MOST, 3.2 million RMB, PI

2018-2022 Changes in arachidonic acid metabolites during the progression of myocardial remodeling, 81790621, NSFC, 4.5 million RMB, PI

2017-2021 Mechanistic study of Beta-arrestin in heart injury and heart failure, 81630008, NSFC, 2.6 million RMB, PI

Major Publications

1. Peng Jiang#, Lejiao Ren#, Li Zhi#, Zhong Yu, Fengxiang Lv, Fengli Xu, Wei Peng, Xiaoyu Bai, Kunlun Cheng, Li Quan, Xiuqin Zhang, Xianhua Wang, Yan Zhang, Dan Yang, Xinli Hu*, Rui-Ping Xiao*. Negative Regulation of AMPK Signaling by High Glucose via E3 Ubiquitin Ligase MG53. Molecular Cell, 2021, 81(3):629-637.

2. Dan Shan#, Sile Guo#, Hong-Kun Wu, Fengxiang Lv, Li Jin L, Mao Zhang, Peng Xie, Yimei Wang, Ying Song, Wu F, Lan F, Hu X, Cao CM*, Zhang Y*, Rui-Ping Xiao*. Cardiac Ischemic Preconditioning Promotes MG53 Secretion through H2O2-activated PKC-d Signaling. Circulation, 2020, 142(11):1077-1091.

3. Ying Song, Chanjuan Xu, Jianfeng Liu, Yulong Li, Huan Wang, Dan Shan, Irving W. Wainer, Xinli Hu, Yan Zhang*, Anthony Yiu-Ho Woo*, Rui-Ping Xiao. Heterodimerization with 5-HT2BR Is Indispensable for β2AR-mediated Cardioprotection. Circulation Research, 2020, 128(2):262-277.

4. Mao Zhang, Hua Gao, Dairu Liu, Xiaoming Zhong, Xiaolu Shi, Peng Yu, Li Jin, Yun Liu, Yajie Tang, Yunhu Song, Jinghao Liu, Xinli Hu, Chuan-Yun Li, Lei Song, Jun Qin, Fujian Wu, Feng Lan, Yan Zhang, Rui-Ping Xiao. CaMKII-d9 Promotes Cardiomyopathy through Disrupting UBE2T-dependent DNA Repair. Nature Cell Biology, 2019, 21:1152-1163.

5. Hong-Kun Wu #, Yan Zhang#, Chun-Mei Cao#, Xinli Hu, Meng Fang, YuanYao, Li Jin, Gengjia Chen, Peng Jiang, Shuo Zhang, Ruisheng Song, Wei Peng, Fenghua Liu, Jiaojiao Guo, Lifei Tang, Yanyun He, Dan Shan, Jin Huang, Zhou Zhou, Dao Wen Wang, Fengxiaong Lv*, Rui-Ping Xiao*. Glucose-sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis. Circulation, 2019, 139:901–914.

6. Yao Xiao#, Can Wang#, Jia-Yu Chen, Fujian Lu, Jue Wang, Ning Hou, Xiaomin Hu, Fanxin Zeng, Dongwei Ma, Xueting Sun, Yi Ding, Yan Zhang, Wen Zheng, Yuli Liu, Haibao Shang, Wenzhen Zhu, Chensheng Han, Yulin Zhang, Kunfu Ouyang, Liangyi Chen, Ju Chen, Rui-Ping Xiao, Chuan-Yun Li*, and Xiuqin Zhang*. Deficiency of PRKD2 Triggers Hyperinsulinemia and Metabolic Disorders. Nature Communication, 2018, 9(1): 2015.

7. Ting Zhang#, Yang Zhang #*, Mingyao Cui, Li Jin, Yimei Wang, Fengxiang Lv, Yuli Liu, Wen Zheng, Haibao Shang, Jun Zhang, Mao Zhang, Hongkun Wu, Jiaojiao Guo, Xiuqin Zhang, Xinli Hu, Chun-Mei Cao*, Rui-Ping Xiao*. CaMKII Is A RIP3 Substrate Mediating Ischemia- and Oxidative Stress-Induced Myocardial Necroptosis. Nature Medicine, 2016, 22(2): 175-182.

8. Weizhong Zhu, Sharon Tsang, David M Browe, Anthony Yh Woo, Ying Huang, Chanjuan Xu, Jian-Feng Liu, Fengxiang Lv, Yan Zhang*, Rui-Ping Xiao*. Interaction of β1-Adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling. JCI Insight, 2016, 1(1): e84969.

9. Fenghua Liu#, Ruisheng Song#, Yuanqing Feng#, Jiaojiao Guo, Yanmin Chen, Yong Zhang, Tao Chen, Yanru Wang, Yanyi Huang, Chuan-Yun Li, Chunmei Cao, Yan Zhang, Xinli Hu*, Rui-Ping Xiao*. Upregulation of MG53 Induces Diabetic Cardiomyopathy through Transcriptional Activation of Peroxisome Proliferation-Activated Receptor α. Circulation, 2015, 131(9): 795-804.

10. Ruisheng Song, Wei Peng, Yan Zhang, Fengxiang Lv, Hong-Kun Wu, Jiaojiao Guo, Yongxing Cao, Yanbin Pi, Xin Zhang, Li Jin, Mao Zhang, Peng Jiang, Fenghua Liu, Shaoshuai Meng, Xiuqin Zhang, Ping Jiang, Chun-Mei Cao*, Rui-Ping Xiao*. Central Role of E3 Ubiquitin Ligase MG53 in Insulin Resistance and Metabolic Disorders. Nature, 2013, 494(7437): 375-379.