National Outstanding Young Scholar

Biography

Dr. Zhuan Zhou is a professor in College of Future Technology, Peking University, China. His research interest is on dopamine/monoamine secretion in physiology and diseases, mechanisms of exocytosis and endocytosis, PD-impaired neural circuits using [Ca]i imaging and DA recordings in awaking rodents, mechanisms of monoamine release from PNS nerves in slices & in vivo, design & developing new methods/tools for physiological recordings. He has been awarded the National Outstanding Young Scholar. He has published over 100 scientific journal papers on peer-reviewed journals including Nature Neuroscience, Neuron, Proc Natl Acad Sci U S A., Nature Communications etc. He was the vice president of Biophysical Society of China (2006-2010) and the chair of neurobiophysical committee (2002-2006, 2006-2010).

Education

n BE 1984  Electronic Engineering and Instrumentation, Tongji University, Shanghai, China

n Ph. D.  1990 Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, China

Experience

n 1990-1993, Postdoctoral fellow in laboratory of Erwin Neher, Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany.

n 1993.02-1995.10, Research Instructor, Departments of Physiology, Washington University. St. Louis, The United States.

n 1993.04-2000.05, Director and Professor, Institute of Biophysics and Biochemistry Huazhong University of Science and Technology, Wuhan, China.

n 1995.11-1997.08, Researcher Assistant Professor, Department of Physiology, Loyola University, Chicago, The United States.

n 1997.09-1999.10, Professor and Head, Department of Neuroscience and Biophysics, University of Science and Technology of China, Hefei, China

n 1999.11-2004.12, Principle Investigator, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China

n 2005.1-2021.3, Professor and Senior Investigator, Institute of Molecular Medicine, Peking University, Beijing, China

n 2021.4-now, Professor and Senior Investigator, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China

Projects:

n 2020.1-2024.12 Principal Investigator, National Natural Science Foundation of China (No. 31930061)

      Title: A study on ion channel, action potential, and quantal secretion in neurons, (RMB 3,030,000)

n 2018.1 – 2022.12 Principal Investigator, National Natural Science Foundation of China (No. 21790394)

      Title: Molecular mechanisms of JD-1 associated Parkinson’s diseases (RMB 4,200,000)

Representative publications:

1. Wang L, Gao M, Wang Q, Sun L, Younus M, Ma S, Liu C, Shi L, Lu Y, Zhou B, Sun S, Chen G, Li J, Zhang Q, Zhu F, Wang C, Zhou Z. Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice.  Nature Communications, 2023,14(1):1568. doi: 10.1038/s41467-023-37045-3..

2. Wang Y, Huang R, Chai Z, Wang C, Du X, Hang Y, Xu Y, Li J, Jiang X, Wu X, Qiao Z, Li Y, Liu B, Zhang X, Cao P, Zhu F, Zhou Z. Ca2+ -independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons. EMBO Reports, 2022,23(11): e54507. doi: 10.15252/embr.202154507 .  

3. Lin Z, Li Y, Hang Y, Wang C, Liu B, Li J, Yin L, Jiang X, Du X, Qiao Z, Zhu F, Zhang Z, Zhang Q, Zhou Z. Tuning the Size of Large Dense-Core Vesicles and Quantal Neurotransmitter Release via Secretogranin II Liquid-Liquid Phase Separation. Advanced Science, 2022,9(27): e2202263. doi: 10.1002/advs.202202263.  

4. Zhu F, Liu L, Li J, Liu B, Wang Q, Jiao R, Xu Y, Wang L, Sun S, Sun X, Younus M, Wang C, Hokfelt T, Zhang B, Gu H, Xu ZD, Zhou Z Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons. Cell Reports, 2022,40(7):111199. doi: 10.1016/j.celrep.2022.111199.  

5. Quanfeng Zhang , Bin Liu , Qihui Wu, Bing Liu , Yinglin Li , Suhua Sun, Yuan Wang, Xi Wu, Zuying Chai, Xiaohan Jiang, Xiaoyao Liu, Meiqin Hu, Yeshi Wang, Yunting Yang, Li Wang, Xinjiang Kang, Yingfei Xiong, Yang Zhou, Xiaoke Chen, Lianghong Zheng, Bo Zhang, Changhe Wang, Feipeng Zhu, Zhuan Zhou*, “Differential co-release of two neurotransmitters from a vesicle fusion pore in mammalian adrenal chromaffin cells.” Neuron,102(1):173-183 (2019).

6. Quanfeng Zhang, Bing Liu, Yinglin Li, Lili Yin, Muhammad Younus, Xiaohan Jiang, Zhaohan Lin, Xiaoxuan Sun, Rong Huang, Bin Liu, Qihui Wu, Feipeng Zhu, Zhuan Zhou*,“Regulating quantal size of neurotransmitter release through a GPCR voltage sensor.” Proc Natl Acad Sci U S A, 2020,117(43):26985-26995.

7. Mingli Li, Huadong Xu, Guoqing Chen, Suhua Sun, Qinglong Wang, Bing Liu, Xi Wu, Li Zhou, Zuying Chai, Xiaoxuan Sun, Yang Lu, Muhammad Younus, Lianghong Zheng, Feipeng Zhu, Hongbo Jia, Xiaowei Chen, Changhe Wang, Zhuan Zhou*,“Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson's disease.” Brain, 2019,142(10):3099-3115.

8. Rong Huang, Yuan Wang, Jie Li, Xiaohan Jiang, Yinglin Li, Bing Liu, Xi Wu, Xingyu Du, Yuqi Hang, Mu Jin, Feipeng Zhu, Changhe Wang*, Zuying Chai*, Zhuan Zhou*,“Ca 2+-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian sympathetic nervous system.”Proc Natl Acad Sci U S A, 2019,116(40):20201-20209.

10. Changhe Wang, Xinjiang Kang, Li Zhou, Zuying Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Suhua Sun, Jie Li, Ruiying Jiao, Panli Zuo, Lianghong Zheng, Zhenyu Yue, Zhuan Zhou*,“Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.” Nature Communications, 2018,9(1):81.

11. Zuying Chai, Changhe Wang, Rong Huang, Yuan Wang, Xiaoyu Zhang, Qihui Wu, Yeshi Wang, Xi Wu, Lianghong Zheng, Chen Zhang, Wei Guo, Wei Xiong, Jiuping Ding, Feipeng Zhu, Zhuan Zhou*,“CaV2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons.” Neuron, 2017,96(6):1317-1326.

12. Li Wang, Shujiang Shang, Xinjiang Kang, Sasa Teng, Feipeng Zhu, Bin Liu, Qihui Wu, Mingli Li, Wei Liu, Huadong Xu, Li Zhou, Ruiying Jiao, Haiqiang Dou 2, Panli Zuo, Xiaoyu Zhang, Lianghong Zheng, Shirong Wang, Changhe Wang, Zhuan Zhou*,“Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine.” Nature Communications, 2014,5:3925.

13. Xiao-Ke Chen, Lie-Cheng Wang, Yang Zhou, Qian Cai, Murali Prakriya, Kai-Lai Duan, Zu-Hang Sheng, Christopher Lingle, Zhuan Zhou*,“Activation of GPCRs modulates quantal size in chromaffin cells through G(betagamma) and PKC.” Nature Neuroscience, 2005,8(9):1160-1168.

14. Zhang C & Zhou Z*, “Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons.”  Nature Neuroscience, 5(5):425-30(2002).

15. Chen Zhan g, Wei Xiong, Hui Zheng, Liecheng Wang, Bai Lu, Zhuan Zhou*,“Calcium- and dynamin-independent endocytosis in dorsal root ganglion neurons.” Neuron, 2004,42(2): 225-36.

16. Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, Fan Meng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Steven F. Dowdy, Neal K. Devaraj, Zhuan Zhou, William C. Mobley, Don W. Cleveland & Xiang-Dong Fu, Rversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature, 2020,582(7813):550-556. doi: 10.1038/s41586-020-2388-4. (my lab contribute the in vivo recordings of dopamine release in PD vs. WT mice. Fig. 5f-k）