Professor

Associate Dean, College of Future Technology

HHMI International Research Scholar

New Cornerstone Investigator

Biography

Ying Liu is a Professor and the Associate Dean of the College of Future Technology at Peking University. She is also a New Cornerstone Investigator, as well as an Investigator with both the PKU-THU Center for Life Sciences (CLS) and the Beijing Advanced Innovation Center for Genomics (ICG).

Dr. Liu earned her B.S. degree in Biochemistry from Nanjing University in China. From 2006 to 2011, she pursued graduate studies in Dr. Qinghua Liu's laboratory at the University of Texas Southwestern Medical Center. In 2011, she began her postdoctoral fellowship in Prof. Gary Ruvkun's laboratory at Massachusetts General Hospital and Harvard Medical School. In December 2013, she established her own independent lab at Peking University.

Our research primarily focuses on deciphering the mechanisms underlying cellular stress responses and homeostatic regulation. Over the past ten years, we have delved into the molecular mechanisms orchestrating cellular and organismal reactions to nutrient scarcity or mitochondrial stress. Currently, we are shifting our research focus to explore the molecular mechanisms that govern age-related decline of stress responses and immune responses.

Education

n BS 2006 Biotechnology, Nanjing University

n PhD  2011 Biochemistry, University of Texas Southwestern Medical Center

Experience

n 2011. 8 – 2014. 2  Postdoc, Massachusetts General Hospital & Harvard Medical School (Advisor: Prof. Gary Ruvkun)

n 2013. 12 – 2019. 8  Assistant Professor, Institute of Molecular Medicine, Peking University  

n 2019. 8 – 2021. 2  Associate Professor, Institute of Molecular Medicine, Peking University

n 2021. 2 – present  Professor, College of Future Technology, Peking University

Representative publications:

1. Zhang J#, Peng Q#, Ma C#, Wang J#, Xiao C, Li T, Liu X, Zhou L, Zhou W, Ding W, An N, Zhang L, Liu Y* and Li C-Y*, 6mA-Sniper: Quantifying 6mA Sites in Eukaryotes at Single-Nucleotide Resolution. Science Advances (2023) 20;9(42):eadh7912.

2. Xu C#, Pan X#, Wang D, Guan Y, Yang W, Chen X* and Liu Y*. O-GlcNAcylation of Raptor transduces glucose signals to mTORC1. Molecular Cell (2023) 83(16):3027-3040.

3. Ma C#, Xue T#, Peng Q#, Zhang J, Guan J, Ding W, Li Y, Xia P, Zhou L, Zhao T, Wang S, Quan L, Li C-Y* and Liu Y*. A novel N6-Deoxyadenine methyltransferase METL-9 modulates C. elegans immunity via dichotomous mechanisms. Cell Research (2023) 33, 628-639.

4. Yan G, Yang J, Li W, Guo A, Guan J and Liu Y*. Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing. Nature Cell Biology (2023) 25(5):754-764.

5. Wang D#, Xu C#, Yang W, Chen J, Ou Y, Guan Y, Guan J and Liu Y*. E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. Molecular Cell (2022) 82(4):770-784.

6. Chen J#*, Ou Y#, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen P and Liu Y*. SAR1B senses leucine levels to regulate mTORC1 signalling. Nature (2021) 596(7871):281-284.

7. Li Y, Ding W, Li C-Y and Liu Y*. HLH-11 modulates lipid metabolism in response to nutrient availability. Nature Communications (2020) 11:5959.

8. Shao L#, Peng Q#, Dong M, Gao K, Li YM, Li Y, Li C-Y* and Liu Y*. Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity. Nature Communications (2020) 11:4639.

9. Gao K, Li Y, Hu SM and Liu Y*. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. eLife (2019) e41792.

10. Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A and Liu Y*. N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation. Nature Cell Biology (2018) DOI: 10.1038/s41556-018-0238-5.

11. Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y and Liu Y*. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Nature 557(2018) 585-589.

12. Shao LW, Niu R and Liu Y*. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Research 11 (2016) 1182-1196.

13. Liu Y, Samuel BS, Breen PC and Ruvkun G. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature (2014) doi:10.1038/nature13204.

14. Liu Y, Tan H, Tian H, Liang C, Chen S and Liu Q. Autoantigen La promotes efficient RNAi, antiviral response and transposon silencing by facilitating multiple-turnover RISC catalysis. Molecular Cell 44 (2011) 502-508.

15. Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch L, Grishin N, Liu Q. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 5941 (2009) 750-753.