Professor, Department of Biomedical Engineering

Associate Dean, Faculty of Information and Engineering, Peking University

Chinese Ministry of Education Appointed Chang-Jiang Distinguished Professor

Leader of molecular imaging Innovation Group, National Natural Science Foundation of China

National Outstanding Young Scientist Award

Principal scientist, National Key Initiative for Scientific Instrumentation

Principal scientist, National Key Basic Research Project (973 Project)

Fellow, American Institute of Medical and Biological Engineering（AIMBE）

Fellow, International Society for Optics and Photonics (SPIE)

Biography

Prof. Ren’s main research interests include: Multi-modality Molecular Imaging; and Biomedical Optics and Laser Medicine.

In the field of Molecular Imaging, Prof. Ren developed some key technologies with novel molecular imaging probes and instrumentation. He successfully devised a hybrid system that integrated CT, PET, SPECT, and Optical Fluorescence Molecular Tomography (FMT) Quad-modality imaging system for small animals. This imaging system provided a versatile research platform for biomedical research and new drug development. Using this newly developed system with novel multi-modal molecular imaging probes, Prof. Ren and his team is currently studying the biological behavior of different sub-types of the cancer cell for personalized cancer diagnosis and treatment. One of Prof. Ren’s contribution to the Chinese medical society is the successful development of the first 64-sliced PET/CT medical imaging system for clinical application in China. Under his leadership, an academic-industrial consortium was established and led to such a successful development which received Chinese Food and Drug Administration (CFDA) approval for commercialization in February, 2014. Because of his accomplishment, Prof. Ren and his team was received the National Innovative Research Group Award in Molecular Imaging given by National Natural Science Foundation of China in July, 2014.

In the field of Biomedical Optics and Laser Medicine, Prof. Ren studied laser-tissue interaction mechanisms and developed several new minimal invasive laser surgeries. He was one of the first to demonstrate that the 213nm laser wavelength generated by 5th harmonic of Q-switched Nd:YAG laser could be a solid-state laser alternative to excimer laser for corneal refractive surgery. This discovery has led to the development of several solid state laser based systems for refractive surgery that were commercialized successfully for the past 10 years. Prof. Ren also studied the mechanism of skin collagen restructuring and regeneration induced by laser treatments. Based on these studies, prof. Ren and his team have developed a series of dermatological laser systems that has been successfully commercialized worldwide.

Prof. Ren has been playing a very active role in IEEE/EMBS Society’s activities and services. He is the associate editor for IEEE Transactions on Information Technology in Biomedicine (TITB), and has served numerous IEEE Conferences or Symposia committee members.

Prof. Ren has published more than 500 academic papers and obtained 2 US patents, 3 international authorized patents and more than 100 domestic authorized patents.. He received National Outstanding Young Scientist Award from the National Natural Science Foundation of China in January, 2006, Distinguished Chang-Jiang Scholar Professorship from the Chinese Ministry of Education in March, 2007. In 2012, he became the Fellow in the American Institute for Medical and Biological Engineering's (AIMBE) College of Fellows. In December 2014, he was selected as the Fellow in the International Society for Optics and Photonics (SPIE). He received National Outstanding Young Scientist Award in January 2006, and the National Innovative Research Group Award in Molecular Imaging in January, 2015, both from National Natural Science Foundation of China

Courses

n Graduate students: Laser Medicine (Elective, 3 credits)

Education

n BE 1984 Department of Optical Engineering, Huazhong University of Science and Technology

n M. Sc 1987 Department of Electrical Engineering, Ohio State University

n Ph. D.  1990 Department of Electrical Engineering, Ohio State University

Experience

n 1991-1994 Assistant Professor, Department of Biomedical Engineering, University of Miami

n 2002-2009 Professor, Department of Biomedical Engineering, Shanghai Jiaotong University

n 2009-present Professor, Department of Biomedical Engineering, School of Engineering, Peking University

Projects:

n 01/2016 – 12/2021 Group Leader and Lead PI, Group Innovation Award in Multi-modality Molecular Imaging, Natural Science Foundation of China (NSFC)

n 10/2011 – 09/2016 Chief Scientist and Principal Investigator, National Key Initiative for Scientific Instrumentation

      Title: Research and Development of Multi-Modality (CT, PET, SPECT, FMT) Molecular Imaging System for Animal Research

      Founding Agencies: China Ministry Of Science and Technology

      Amount: ￥55.1million

n 01/2011 – 10/2015 Chief Scientist and Principle Investigator, National Key Basic Research Project (973 Project):

      Title : Visual Prosthesis for Blind People and Related Key Technologies

      Founding Agency: Chinese Ministry of Science and Technology

      Amount: ￥26.8million

n 01/2008 – 12/2012 Principal Investigator, International Expert Exchange for Innovation in Science and Technology (111 Program)

      Title: Advanced Minimal Invasive Medical Technology Development

      Founding Agencies:  State Administration of Foreign Experts Affairs and

      Ministry of Education of China

      Amount: ￥4.5million

n 12/2007 – 11/2010  Principal Investigator, National Key Technologies R&D Program

      Title: Distributed Wireless Biosensor Technologies for Emergency Care

      Founding Agency: Chinese Ministry of Science and Technology

      Amount: ￥2million

n 11/2005 – 10/2010 Chief Scientist and Principle Investigator, National Key Basic Research Project (973 Project):

      Title : Visual Prosthesis for Blind People and Related Key Technologies

      Founding Agency: Chinese Ministry of Science and Technology

      Amount: ￥30million

n 11/2005 – 10/2009 National Outstanding Young Scientist Award

      Title: Investigation on Basic Mechanism and Key Technologies for Visual Prosthesis

      Funding Agency: China Natural Science Foundation

      Amount: ￥1million

n 10/2005 – 09/2007 Principle Investigator

      Title: Laser Tissue Interaction and Its Applications in Minimal Invasive Surgery

      Founding Agency: Shanghai Commission for Science and Technology

      Amount: ￥900,000.00

n 09/2004 – 08/2006 Principle Investigator

      Title: Optical-Electrical Micro-System (OEMS) for Implantable Visual Prosthesis

      Founding Agency: Shanghai Commission for Science and Technology

      Amount: ￥600,000.00

n 12/2003 – 11/2006 Principle Investigator

      Title: Laser Hyper-polarized Noble Gas Enhanced MR Imaging for Lung Diseases

      Founding Agency: Shanghai Commission for Science and Technology

      Amount: ￥800,000.00

n 01/2004 – 12/2006 Principal Investigator

      Title: Non-Invasive Endo-Confocal Imaging for Early Detection of Cell Malformation

      Founding Agency: Chinese Natural Science Foundation

      Amount: ￥260,000.00

Representative publications:

1. Zhe Jiang, Zhiyu Huang, Bin Qiu, Xiangxi Meng, Yunfei You, Xi Liu, Mufeng Geng, Gangjun Liu, Chuanqing Zhou, Kun Yang, Andreas Maier, Qiushi Ren, Yanye Lu. “Weakly Supervised Deep Learning Based Optical Coherence Tomography Angiography,” IEEE Transactions on Medical Imaging 40, 688-698 (2021).

2. Mufeng Geng, Zifeng Tian, Zhe Jiang, Yunfei You, Ximeng Feng, Yan Xia, Kun Yang, Qiushi Ren, Xiangxi Meng, Andreas Maier, Yanye Lu, "PMS-GAN: Parallel Multi-Stream Generative Adversarial Network for Multi-Material Decomposition in Spectral Computed Tomography," IEEE Transactions on Medical Imaging 40, 571-584 (2021).

3. Ximeng Feng, Da Zou, Yicheng Hu, Zhiyu Huang, Zheng Gu, Chuangqing Zhou, Gangjun Liu, Qiushi Ren, Yanye Lu. “Rapid, wide-field, high quality laser speckle angiography for retinal and choroidal vessels,” Laser Physics Letters, 18, 055601 (2021).

4. Zhiyi Wang#, Ziyuan Li#, Zhaoli Sun, Shuren Wang, Zeeshan Ali, Sihao Zhu, Sha Liu, Qiushi Ren, Fugeng Sheng, Baodui Wang, Yanglong Hou, "Visualization nanozyme based on tumor microenvironment 'unlocking' for intensive combination therapy of breast cancer," Science Advances, 6(48):eabc8733 (2020).

5. Zhiyu Huang, Zhe Jiang, Yicheng Hu, Da Zou, Yue Yu, Qiushi Ren, Gangjun Liu, Yanye Lu, "Retinal choroidal vessel imaging based on multi-wavelength fundus imaging with the guidance of optical coherence tomography," Biomedical Optics Express 11, 5212-5224 (2020).

6. Bin Qiu, Zhiyu Huang, Xi Liu, Xiangxi Meng, Yunfei You, Gangjun Liu, Kun Yang, Andreas Maier, Qiushi Ren, Yanye Lu*, “Noise reduction in optical coherence tomography images using a deep neural network with perceptually-sensitive loss function,” Biomedical Optics Express 11, 817-830 (2020).

7. Zhaoheng Xie, Suying Li, Kun Zhou, Ivan Vuletic, Xiangxi Meng, Sihao Zhu, Huan Xu, Kun Yang*, Baixuan Xu, Jinming Zhang, Qiushi Ren, “PKU-PET-II: A novel SiPM-based PET imaging system for small animals,” Nuclear Instruments & Methods In Physics Research Section A 877, 104-111 (2018).

8. Kun Zhou, Jian Tian, Xiangxi Meng, Kun Yang, Baixuan Xu, Zhi Yang, Qiushi Ren, “A Novel Scatter Correction Method for Cone-Beam Computed Tomography,” Journal of Computer Assisted Tomography 40, 632-638 (2016).

9. Yanye Lu, Kun Yang, Kedi Zhou, Bo Pang, Guohe Wang, Yichen Ding, Qiushi Zhang, Hongbin Han, Jiahe Tian, Changhui Li, Qiushi Ren, “An Integrated Quad-Modality Molecular Imaging System for Small Animals,” Journal of Nuclear Medicine 743, 30-38 (2014).

10. Yanye Lu, Kun Yang, Kedi Zhou, Qiushi Zhang, Bo Pang, Qiushi Ren, “Development of a SiPM-based PET imaging system for small animals,” Nuclear Instruments & Methods In Physics Research Section A 743, 30-38 (2014).