教育背景

2014.09-2019.07，清华大学，生命科学学院，博士，导师陈晔光院士

2010.09-2014.07，中国农业大学，生物学院，本科

工作经历

2025.11-至今，北京大学未来技术学院，助理研究员

2024.12-2025.10，中国科学院生物物理研究所，助理研究员

2019.07-2024.05，清华大学生命科学学院，博士后（合作导师陈晔光院士）

承担项目

1.     2018.01-2022.12 / HER2/EGFR信号调控TGF-β在控制细胞增殖与EMT和细胞迁移之间的功能转换及机制 / 国家自然科学基金重点项目 /参与

2.    2022.01-2024.12 / Dishevelled相分离对Wnt信号通路转导及功能影响的研究 / 国家自然科学基金青年科学基金项目 /主持

代表性论文

1. Shi Q, Huang F, Wang Y, Liu H, Deng H, Chen YG^#. HER2 phosphorylation induced by TGF-β promotes mammary morphogenesis and breast cancer progression. J Cell Biol. 2024 Apr 1;223(4):e202307138. 

2. Cui Y*, Shi Q*, Song P, Tong J, Cheng Z, Zhang H, Wang X, Zheng Y, Wu Y, Wan M, Li S, Zhao X, Tong Z, Yu Z, Gao S^#, Chen YG^#, Gao GF^#. Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling. J Exp Med. 2024 Aug 5;221(8):e20231512. 

3. Kmiecik SW^#, Shi Q^#, Chen YG^#, Moormann J^#, Hildebrandt TM^#, Schade A^#, Fischer M^#, Kim KQ^#. Crafting figures to describe cellular processes. Trends Biochem Sci. 2023 Jun;48(6):491-494. 

4. Kang K*, Shi Q*, Wang X, Chen YG^#. Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly. J Cell Biol. 2022 Dec 5;221(12):e202205069.

5. Shi Q, Chen YG^#. Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy. Trends Biochem Sci. 2021 Dec;46(12):1003-1016. 

6. Shi Q, Kang K, Chen YG^#. Liquid-liquid phase separation drives the β-catenin destruction complex formation. Bioessays. 2021 Oct;43(10):e2100138. 

7. Nong J*, Kang K*, Shi Q*, Zhu X, Tao Q, Chen YG^#. Phase separation of Axin organizes the β-catenin destruction complex. J Cell Biol. 2021 Apr 5;220(4):e202012112.

8. Shi Q, Chen YG^#. ALK-mediated Tyr95 phosphorylation of Smad4 impairs its transcription activity and the tumor suppressive activity of TGF-beta. Sci China Life Sci. 2019 Mar;62(3):431-432. 

9. Shi Q, Chen YG^#. The functional switch of TGF-β signaling in breast cancer. Oncotarget. 2019 Feb 26;10(17):1604-1605. 

10. Huang F*, Shi Q*, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG^#. HER2/EGFR-AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer. Cancer Res. 2018 Nov 1;78(21):6073-6085.

11. Shi Q, Chen YG^#. Interplay between TGF-β signaling and receptor tyrosine kinases in tumor development. Sci China Life Sci. 2017 Oct;60(10):1133-1141.