个人简介
陈雷课题组的主要研究方向为与代谢类疾病和心血管疾病密切相关的重要蛋白的工作机制，特别是离子通道和转运蛋白。陈雷课题组以结构生物学、生物化学、细胞生物学、生物物理、电生理等方法来研究这些蛋白的工作机理。陈雷课题组在血糖间接感受器KATP通道、糖尿病靶点SGLT2、产热素UCP1、一氧化氮受体sGC和NADPH氧化酶等方面取得了一定进展。
所授课程
本科生和研究生合上：
《蛋白质结构分析》
研究生：
《离子通道门控机制研究进展》
《膜蛋白研究前沿进展研讨》
教育背景
2001-2005 清华大学生物科学与技术系 本科
2005-2010 清华大学生命科学学院 博士
工作经历
2010–2016 美国俄勒冈健康与科学大学 博士后
2016–现在 北京大学未来技术学院 分子医学研究所 研究员 博士生导师
承担项目
国家自然科学基金 杰出青年项目 (课题负责人，项目编号32225027，2023.01-2027.12)
国家自然科学基金 重点项目（课题负责人，项目编号32430050，2025.01-2029.12）
代表性论文
1. X. He, W. Tao, Y. Kang, J. Xu, X. Liu and L. Chen. Structural polymorphism of the antigenic loop in HBV surface antigen dictates binding of diverse neutralizing antibodies. in Cell Discov, 2025, 20250617 edn Vol. 11 57.
2. X. Liu, Y. Shi, R. Liu, K. Song and L. Chen. Structure of human phagocyte NADPH oxidase in the activated state. in Nature, 2024, 20240214 edn Vol. 627 189-195.
3. Y. Kang and L. Chen. Structural basis for the binding of DNP and purine nucleotides onto UCP1. in Nature, 2023, 2023/06/20 edn Vol. 620 226-231.
4. D. Ding, T. Hou, M. Wei, J. X. Wu and L. Chen. The inhibition mechanism of the SUR2A-containing K(ATP) channel by a regulatory helix. in Nat Commun, 2023, 2023/06/18 edn Vol. 14 3608
5. Y. Kang and L. Chen. Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex. in Nat Commun, 2022, 2022/05/14 edn Vol. 13 2639.
6. W. Guo, Q. Tang, M. Wei, Y. Kang, J. X. Wu and L. Chen. Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. in Neuron, 2022, 2022/01/21 edn Vol. 110 1023-1035 e5.
7. Y. Niu, R. Liu, C. Guan, Y. Zhang, Z. Chen, S. Hoerer, H. Nar and L. Chen. Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter. in Nature, 2021, 2021/12/08 edn Vol. 601 280-284.
8. Y. Kang, R. Liu, J. X. Wu and L. Chen. Structural insights into the mechanism of human soluble guanylate cyclase. in Nature, 2019, 2019/09/13 edn Vol. 574 206-210.
9. N. Li, J. X. Wu, D. Ding, J. Cheng, N. Gao and L. Chen. Structure of a Pancreatic ATP-Sensitive Potassium Channel. in Cell, 2017, 2017/01/14 edn Vol. 168 101-110 e10.
10. K. L. Durr, L. Chen, R. A. Stein, R. De Zorzi, I. M. Folea, T. Walz, H. S. McHaourab and E. Gouaux. Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states. in Cell, 2014, 2014/08/12 edn Vol. 158 778-792.
11. L. Chen, K. L. Durr and E. Gouaux. X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. in Science, 2014, 2014/08/12 edn Vol. 345 1021-6.
12. L. Chen, J. Wang, Y. Y. Zhang, S. F. Yan, D. Neumann, U. Schlattner, Z. X. Wang and J. W. Wu. AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. in Nature Structural and Molecular Biology, 2012, 2012/06/05 edn Vol. 19 716-8.
13. L. Chen, Z. H. Jiao, L. S. Zheng, Y. Y. Zhang, S. T. Xie, Z. X. Wang and J. W. Wu. Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. in Nature, 2009, 2009/05/29 edn Vol. 459 1146-9.
