实验室：心脏疾病与表观遗传学研究室

研究方向:利用表观遗传学操控技术促进造血干祖细胞体外生成

论文：

1、Li, C.C.*, Zhang, G.*, Du, J., Liu, D., Li, Z., Ni, Y., Zhou, J., Li, Y., Hou, S., Zheng, X., Lan, Y., Liu, B. and He, A. (2022). Pre-configuring chromatin architecture with histone modifications guides hematopoietic stem cell formation in mouse embryos. Nature Communications 13(1):346.

2、Li, Y.*, Li, C.*, Li, S., Peng, Q., An, N.A., He, A., and Li, C.Y. (2018). Human exonization through differential nucleosome occupancy. Proc Natl Acad Sci U S A 115, 8817-8822.

3、Zhang, J.*, Li, C.C.*, Liu, Y., Wang, Q., Xiong, H., Li, X., He, A. and Ai, S. A temporal hierarchy of lncRNA-embedding enhancers for Nkx2-5 regulation during heart development. Revision.

4、Ai, S.*, Xiong, H.*, Li, C.C., Luo, Y., Shi, Q., Liu, Y., Yu, X., Li, C., and He, A. (2019). Profiling chromatin states using single-cell itChIP-seq. Nature Cell Biology 21, 1164-1172.

5、Ai, S.*, Peng, Y.*, Li, C., Gu, F., Yu, X., Yue, Y., Ma, Q., Chen, J., Lin, Z., Zhou, P., Xie, H., Prendiville T.W., Zheng, W., Liu, Y., Orkin S.H., Wang, D.Z., Yu, J., Pu W.T., and He, A. (2017). EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife 6. e24570.

6、Li, Y.*, Ai, S.*, Yu, X.*, Li, C., Li, X., Yue, Y., Wei, Y., Li, C.Y., and He, A. (2019). Replication-independent histone turnover underlines the epigenetic homeostasis in adult heart. Circulation Research 125, 198-208.

7、Chang, L.*, Li, M.*, Shao, S.*, Li, C., Ai, S., Xue, B., Hou, Y., Zhang, Y., Li, R., Fan, X., He, A., Li, C., and Sun, Y. (2020). Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells. Protein Cell. doi: 10.1007/s13238-020-00794-8.

8、Ai, S.*, Yu, X.*, Li, Y.*, Peng, Y., Li, C., Yue, Y., Tao, G., Li, C., Pu, W.T., and He, A. (2017). Divergent requirements for EZH1 in heart development versus regeneration. Circulation Research 121, 106-112.

9、Yang, R.*, Cheng, S.*, Luo, N.*, Gao, R., Yu, K., Kang, B., Wang, L., Zhang, Q., Fang, Q., Zhang, L., Li, C., He, A., Hu, X., Peng, J., Ren, X., and Zhang, Z. (2019). Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis. Genome Biology 21, 2.

10、Zhang, M.*, Dong, Y.*, Hu, F.*, Yang, D., Zhao, Q., Lv, C., Wang, Y., Xia, C., Weng, Q., Liu, X., Li, C., Zhou, P., Wang, T., Guan, Y., Guo, R., Liu, L., Geng, Y., Wu, H., Du, J., Hu, Z., Xu, S., Chen, J., He, A., Liu, B., Wang, D., Yang, Y.G., and Wang, J. (2018). Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. Nature Immunology 19, 279-290.

11、Yang, Y.*, Liu, B.*, Xu, J.*, Wang, J.*, Wu, J.*, Shi, C., Xu, Y., Dong, J., Wang, C., Lai, W., Zhu, J., Xiong, L., Zhu, D., Li, X., Yang, W., Yamauchi T., Sugawara A., Li, Z., Sun, F., Li, X., Li, C., He, A., Du, Y., Wang, T., Zhao, C., Li, H., Chi, X., Zhang, H., Liu, Y., Li, C., Duo, S., Yin, M., Shen, H., Belmonte JCI., and Deng, H. (2017). Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell 169, 243-257.e225.

12、何爱彬，李晨，艾珊珊，微量细胞ChIP法（2018），发明专利，申请公布号：CN108315387A，专利号：ZL201810121175.6.