简介：

焦建伟，中国科学院动物研究所研究员。生理学会干细胞生理专业委员会主委。获得国家杰青，万人领军，创新群体首席科学家，国家重点研发首席科学家。承担科技部重点专项，基金委创新群体、杰青、重点、重大研究计划、原创探索项目，中科院先导专项等。主要从事神经干细胞和脑发育机制研究，探索脑发育疾病机理，为脑疾病诊治提供潜在靶点，为转化研究奠定理论基础。研究成果发表于国际期刊Cell, Nat Neurosci, Cell Stem Cell, Dev Cell等80多篇。目前是生理学会理事，神经学会理事等，是杂志Fundamental Research, Cell Proliferation等编委。获得华夏医学科技奖，干细胞创新科学奖，妇幼健康科学技术奖等。

摘要：

The mammalian brain contains millions of neurons and glial cells. Normal cerebral brain development plays an important role in controlling behavior, learning and cognition. During neurogenesis, neural progenitor cells (NPCs) proliferate and differentiate into neurons of cortical layers, which are precisely controlled by various intracellular and extracellular signaling pathways. NPCs of the brain are mainly PAX6-positive apical progenitor cells and TBR2-positive basal progenitor cells. Although more and more molecules are reported involved in the proliferation of progenitor cells, how neurogenesis is regulated by epigenetic factors during the embryonic development of the cerebral cortex remains largely to be investigated. Here, we found a series of epigenetic molecules and modifications are essential for the proliferation and self-renewal of neural stem cells.