The Engineering Research Center of Primate and Large Animal Preclinical Research (Ministry of Education) is a premier preclinical research hub distinguished by its focus on non-human primates.

Since its establishment in 2005, the Center has built a robust infrastructure for translational medicine. It has successfully developed a comprehensive suite of disease models for major conditions—including metabolic syndrome, hypertension, type 2 diabetes, atherosclerosis, myocardial infarction, and heart failure. Complementing these models is a sophisticated array of cardiovascular assessment technologies, including hemodynamic monitoring in conscious animals, 2D speckle-tracking, coronary flow reserve (CFR), dobutamine stress echocardiography (DSE), intima-media thickness (IMT) measurement, and flow-mediated dilation (FMD). These capabilities enable the Center to conduct rigorous, standardized preclinical evaluations for novel drugs and medical devices.

Beyond contract research, the Center serves as a vital bridge between basic discovery and clinical application. Leveraging its unique disease models, it has established specialized platforms spanning experimental pathology, bioanalysis, metabolomics, transcriptomics, and proteomics. By integrating these technologies, the Center generates systematic datasets to elucidate disease mechanisms, identify drug targets, and discover biomarkers. Its collaborative projects with leading international pharmaceutical companies have provided critical evidence to inform clinical trial design and regulatory strategies, solidifying its role as a world-class base for translational biomedical research.