个人简介

Dr. Lei Chen is an investigator in College of Future Technology, Peking University, China. His research interest is on the structural mechanism of proteins involved in human diseases, especially cardiovascular disease and metabolic diseases. His lab has determined the structures of several important drug targets, including the metabolic sensor KATP channel (2017), the nitric oxide receptor soluble guanylate cyclase (2019), and the glucose transporter SGLT2 (2021).

所授课程

> Protein Structure Analysis (1 credit)

> Progress on Research of Ion channel Gating Mechanism (2 credits)

> Progress on Research of Membrane Proteins (2 credits)

教育背景

> BS 2005 Biology, Tsinghua University

> Ph. D.  2010 Biology, Tsinghua University

工作经历

> 2010.10 – 2016.3 Postdoc, Oregon Health and Science University

> 2006.3 – 2021.1 Investigator, Institute of Molecular Medicine, Peking University

> 2021.1 – now Investigator, College of Future Technology, Peking University

代表性论文

1. X. He, W. Tao, Y. Kang, J. Xu, X. Liu and L. Chen. Structural polymorphism of the antigenic loop in HBV surface antigen dictates binding of diverse neutralizing antibodies. in Cell Discov, 2025, 20250617 edn Vol. 11 57.

2. X. Liu, Y. Shi, R. Liu, K. Song and L. Chen. Structure of human phagocyte NADPH oxidase in the activated state. in Nature, 2024, 20240214 edn Vol. 627 189-195.

3. Y. Kang and L. Chen. Structural basis for the binding of DNP and purine nucleotides onto UCP1. in Nature, 2023, 2023/06/20 edn Vol. 620 226-231.

4. D. Ding, T. Hou, M. Wei, J. X. Wu and L. Chen. The inhibition mechanism of the SUR2A-containing K(ATP) channel by a regulatory helix. in Nat Commun, 2023, 2023/06/18 edn Vol. 14 3608

5. Y. Kang and L. Chen. Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex. in Nat Commun, 2022, 2022/05/14 edn Vol. 13 2639.

6. W. Guo, Q. Tang, M. Wei, Y. Kang, J. X. Wu and L. Chen. Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. in Neuron, 2022, 2022/01/21 edn Vol. 110 1023-1035 e5.

7. Y. Niu, R. Liu, C. Guan, Y. Zhang, Z. Chen, S. Hoerer, H. Nar and L. Chen. Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter. in Nature, 2021, 2021/12/08 edn Vol. 601 280-284.

8. Y. Kang, R. Liu, J. X. Wu and L. Chen. Structural insights into the mechanism of human soluble guanylate cyclase. in Nature, 2019, 2019/09/13 edn Vol. 574 206-210.

9. N. Li, J. X. Wu, D. Ding, J. Cheng, N. Gao and L. Chen. Structure of a Pancreatic ATP-Sensitive Potassium Channel. in Cell, 2017, 2017/01/14 edn Vol. 168 101-110 e10.

10. K. L. Durr, L. Chen, R. A. Stein, R. De Zorzi, I. M. Folea, T. Walz, H. S. McHaourab and E. Gouaux. Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states. in Cell, 2014, 2014/08/12 edn Vol. 158 778-792.

11. L. Chen, K. L. Durr and E. Gouaux. X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. in Science, 2014, 2014/08/12 edn Vol. 345 1021-6.

12. L. Chen, J. Wang, Y. Y. Zhang, S. F. Yan, D. Neumann, U. Schlattner, Z. X. Wang and J. W. Wu. AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. in Nature Structural and Molecular Biology, 2012, 2012/06/05 edn Vol. 19 716-8.

13. L. Chen, Z. H. Jiao, L. S. Zheng, Y. Y. Zhang, S. T. Xie, Z. X. Wang and J. W. Wu. Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. in Nature, 2009, 2009/05/29 edn Vol. 459 1146-9.