教育背景

Ph.D. in Life Sciences | Tsinghua University, Beijing, China | Sep 2014 – Jul 2019| Advisor: Academician Chen Yeguang

B.S. in Biological Sciences | China Agricultural University, Beijing, China | Sep 2010 – Jul 2014

工作经历

Assistant researcher | Institute of Future Technology, Peking University | Nov 2025 – Present

Assistant researcher | Institute of Biophysics, Chinese Academy of Sciences | Dec 2024 – Oct 2025

Postdoctoral Fellow | School of Life Sciences, Tsinghua University | Jul 2019 – May 2024 | Advisor: Academician Chen Yeguang

承担项目

Participant | TGF-β Regulation by HER2/EGFR Signaling in the Functional Switch Between Cell Proliferation and EMT/Migration | Key Program of the National Natural Science Foundation | Jan 2018 – Dec 2022

 

Principal Investigator | Phase Separation of Dishevelled and Its Role in Wnt Signaling Transduction and Function | Young Scientists Fund of the National Natural Science Foundation | Jan 2022 – Dec 2024

代表性论文

1. Shi Q, Huang F, Wang Y, Liu H, Deng H, Chen YG^#. HER2 phosphorylation induced by TGF-β promotes mammary morphogenesis and breast cancer progression. J Cell Biol. 2024 Apr 1;223(4):e202307138. 

2. Cui Y*, Shi Q*, Song P, Tong J, Cheng Z, Zhang H, Wang X, Zheng Y, Wu Y, Wan M, Li S, Zhao X, Tong Z, Yu Z, Gao S^#, Chen YG^#, Gao GF^#. Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling. J Exp Med. 2024 Aug 5;221(8):e20231512. 

3. Kmiecik SW^#, Shi Q#, Chen YG^#, Moormann J^#, Hildebrandt TM^#, Schade A^#, Fischer M^#, Kim KQ^#. Crafting figures to describe cellular processes. Trends Biochem Sci. 2023 Jun;48(6):491-494. 

4. Kang K*, Shi Q*, Wang X, Chen YG^#. Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly. J Cell Biol. 2022 Dec 5;221(12):e202205069.

5. Shi Q, Chen YG^#. Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy. Trends Biochem Sci. 2021 Dec;46(12):1003-1016. 

6. Shi Q, Kang K, Chen YG^#. Liquid-liquid phase separation drives the β-catenin destruction complex formation. Bioessays. 2021 Oct;43(10):e2100138. 

7. Nong J*, Kang K*, Shi Q*, Zhu X, Tao Q, Chen YG^#. Phase separation of Axin organizes the β-catenin destruction complex. J Cell Biol. 2021 Apr 5;220(4):e202012112.

8. Shi Q, Chen YG^#. ALK-mediated Tyr95 phosphorylation of Smad4 impairs its transcription activity and the tumor suppressive activity of TGF-beta. Sci China Life Sci. 2019 Mar;62(3):431-432. 

9. Shi Q, Chen YG^#. The functional switch of TGF-β signaling in breast cancer. Oncotarget. 2019 Feb 26;10(17):1604-1605. 

10. Huang F*, Shi Q*, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG^#. HER2/EGFR-AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer. Cancer Res. 2018 Nov 1;78(21):6073-6085.

11. Shi Q, Chen YG^#. Interplay between TGF-β signaling and receptor tyrosine kinases in tumor development. Sci China Life Sci. 2017 Oct;60(10):1133-1141.