Accumulating evidence suggests that solute carrier (SLC) transporters contribute to the etiology of various human diseases. SLC transporter serves as “Metabolic Gate” of cells and mediates the transport of a wide range of essential nutrients and metabolites. Pharmacologically, many SLC transporters have been developed as drug target to treat diabetes, gout and neurological disorders etc. Since joining Tsinghua, Dr. Chen’s group aims to dissect the physiological and pharmacological functions of important SLCs in Mendelian diseases or specific tissue pattern. In this talk, he will introduce two recent research advances on SLC mediated metabolic regulation: 1, SLC Remodelling Metabolic Tissues with endogenous substrate identification, metabolic signalling and molecular mechanism; 2, SLC Shaping Immunity mainly on creatine and monocarboxylate transporters that induce robust metabolic reprogramming, thereby controlling diverse immunological responses.

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清华大学药学院教授，副院长。本科毕业于南开大学化学系，分别在加州大学伯克利分校和旧金山分校获得博士学位和进行博士后训练。 主要研究重要SLC转运蛋白的生理和药理功能，发现了多种转运蛋白的内源性底物以及他们在代谢性疾病、癌症和免疫系统中的代谢调控和致病机理, 为这些疾病治疗提供了潜在的药物靶点和新的治疗策略。在 Immunity、Gut，Hepatology 和 Nat Commun 等发表论文60余篇。曾获得多个奖项包括国家“万人计划”中青年科技创新领军人才，海外高层次青年人才支持计划。曾主持多个科技部重点研发计划、国家基金委重点项目、重大新药创制等。