Abstract：After ribosome translation, proteins need to be transported to different locations for proper functioning. Organelle membranes pose major physical barriers for protein movement in cells, including the lipid membranes of the endoplasmic reticulum (ER), lysosomes, and mitochondria. Cells have evolved a variety of sophisticated protein translocation systems to facilitate the movement of proteins across or into lipid membranes. These translocation systems are highly efficient in creating cross-membrane pathways for proteins while preventing the movement of small molecules, ions, and water. Defects in protein translocation have been associated with numerous human diseases. In this talk, I will first introduce the general concepts of protein translocation systems, using the classic Sec complexes in the secretory pathway as an example. Then, I will discuss the recent 're-discovery' of protein translocases for mitochondrial protein import and its implications for the general working mechanisms of protein translocation.

报告人简介：李龙，北京大学生命科学学院/北大-清华生命科学联合中心研究员。实验室主要利用结构生物学和生物化学等方法研究生物大分子的跨膜运输过程，在过去五年里，聚焦蛋白质跨越内质网和线粒体膜的过程研究，对Sec和TOM-TIM复合物进行了深入研究，揭示了它们在控制蛋白转运机理方面的异同。