Long noncoding RNAs (lncRNAs) are emerging as new regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Many lncRNAs are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced like mRNAs. By developing methods for genome-wide discovery and characterization of non-polyadenylated RNAs, we have identified several RNA species with unexpected formats. These RNAs are derived from long primary transcripts via unusual RNA processing pathways and are stabilized by distinct mechanisms, including capping by small nucleolar RNA (snoRNA)–protein (snoRNP) complexes at their ends (sno-lncRNAs) or forming circular structures. We have shown that some such RNAs are involved in key gene regulation events and are also implicated in human diseases. I will discuss general mechanisms governing their formation and subcellular localization, as well as their emerging functions and potential applications.

报告人简介：

陈玲玲，2000年本科毕业于兰州大学，2003年硕士毕业于中科院上海药物所，2009年博士毕业于美国康涅狄格大学，2011年起任中科院分子细胞科学卓越创新中心（原生化与细胞所）研究组长。2023年入选新基石研究员。

从事核糖核酸（RNA）生物学研究。创建并利用新技术体系，发现sno-lncRNA、SPA和环形RNA等新型分子家族，揭示它们的生成加工与降解途径、参与细胞核亚结构功能和天然免疫调控、并与小胖威利征和自身免疫等疾病密切关联。相关研究做为通讯作者发表在Cell、Nature、Science、Mol Cell、Nat Methods、Nat Cell Biol等。受邀在Cell、Science、Nat Rev Mol Cell Biol等期刊总结和展望领域前沿进展。

受邀担任Cell、Science等期刊编委，国际RNA学会、美国冷泉港实验室、冷泉港亚洲、EMBO、Keystone等多个RNA主题学术会议的大会组织者；任中国生物化学与分子生物学会基因专业分会主任、中国生物物理学会第十二届常务理事等职服务领域。曾任全球华人生物学家协会理事，入选HHMI国际研究学者和国家基金委杰出青年科学基金。获中国青年科技奖(特别奖)、中国青年女科学家奖、科学探索奖、国际RNA学会“Mid-Career Res Award”等学术奖励。