实验室：结构生物学研究室

研究方向: 离子通道以及转运体的结构以及调控研究

论文：

1、Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L. Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron. 2022 Mar 16;110(6):1023-1035.e5. doi: 10.1016/j.neuron.2021.12.023. Epub 2022 Jan 19. PMID: 35051376.

2、Guo W, Wang M, Chen L. A co-expression vector for baculovirus-mediated protein expression in mammalian cells. Biochem Biophys Res Commun. 2022 Feb 26;594:69-73. doi: 10.1016/j.bbrc.2022.01.056. Epub 2022 Jan 19. PMID: 35074588.

3、Song K, Wei M, Guo W, Quan L, Kang Y, Wu JX, Chen L. Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife. 2021 Mar 8;10:e63429. doi: 10.7554/eLife.63429. PMID: 33683200; PMCID: PMC7987348.

4、Guo W, Chen L. Recent progress in structural studies on canonical TRP ion channels. Cell Calcium. 2019 Nov;83:102075. doi: 10.1016/j.ceca.2019.102075. Epub 2019 Aug 28. PMID: 31491644.

5、Tang Q, Guo W, Zheng L, Wu JX, Liu M, Zhou X, Zhang X, Chen L. Structure of the receptor-activated human TRPC6 and TRPC3 ion channels. Cell Res. 2018 Jul;28(7):746-755. doi: 10.1038/s41422-018-0038-2. Epub 2018 Apr 26. PMID: 29700422; PMCID: PMC6028632.