助理教授、研究员、博士生导师
北京大学未来技术学院、国家生物医学成像科学中心
“跨尺度细胞分泌生理学”实验室PI
个人简介
“跨尺度细胞分泌生理学”实验室将整合包括生物物理学（电生理学、电化学）、光学成像（超分辨荧光成像、多光子成像、TIRF成像）、电镜成像、分子细胞生物学、结构生物学等领域，探究神经-内分泌系统互作机理及功能。目前实验室处于筹备阶段，诚挚欢迎相关专业的学生和学者加入。近五年，一系列研究（Neuron, 2019; Journal of Neuroscience, 2019; PNAS，2020；Advanced Science, 2022；Neuroscience Bulletin，2024），在神经递质分泌检测方法及其可塑性调控领域处于国际领先水平。曾获国际嗜铬细胞协会（ISCCB）Daniel T. O’Connor Memorial Early Career Researcher Award、国家“博新计划”博士后、北京大学“优秀博士后”、国家奖学金等奖励。
教育背景
2009-2013 中南大学，学士（生物工程）
2013-2019 北京大学，博士 （整合生命科学-生物学，导师：周专教授）
工作简历
2019.7-2024.4 北京大学 博士后
2024.5至今 北京大学未来技术学院，国家生物医学成像中心，助理教授、研究员
承担项目
主持国家自然科学基金（2021）、国家博新计划（2019）以及中国博士后面上基金（2021）。
代表性论文
1. Zhang QF#,*, Lin ZH#, Du XY#, and Zhou Z*. Liquid-liquid phase separation within dense-core vesicles in sympathetic adrenal chromaffin cells. 2024. Neuroscience Bulletin. 10.1007/s12264-024-01201-6.
2. Lin ZH#, Li YL#, Hang YQ#, Wang CH, Liu B, Li J, Yin LL, Jiang XH, Du XY, Qiao ZJ, Zhu FP, Zhang Z*, Zhang QF*, Zhou Z*. Tuning the size of large dense-core vesicles and quantal neurotransmitter release via secretogranin II liquid-liquid phase separation. 2022. Advanced Science. 2202263.
3. Zhang QF#，Liu B#, Li YL#, Yin LL, Younus M, Jiang XH, Lin ZH, Sun XX, Huang R, Liu Bin, Wu QH, Zhu FP, and Zhou Z*. Regulating quantal size of neurotransmitter release through a GPCR voltage sensor. 2020. Proc Natl Acad Sci U S A. 117(43):26985-26995.
4. Zhang QF#, Liu B#, Wu QH#, Liu B, Li YL, Sun SH, Wang Y, Wu X, Chai ZY, Jiang XH, Liu XY, Hu MQ, Wang Y, Yang Y, Wang L, Kang XJ, Xiong YF, Zhou Y, Chen XK, Zheng LH, Zhang B, Wang CH, Zhu FP, Zhou Z*. Differential Co-release of Two Neurotransmitters from a Vesicle Fusion Pore in Mammalian Adrenal Chromaffin Cells. 2019. Neuron. 102(1):173-183.
5. Wu QH#, Zhang QF#, Liu B, Li YL, Wu X, Kuo ST, Zheng LH, Wang CH, Zhu FP, Zhou Z*. Dynamin 1 Restrains Vesicular Release to a Subquantal Mode In Mammalian Adrenal Chromaffin Cells. 2019. Journal of Neuroscience 39(2): 199-211.
6. Wang L, Gao M, Wang QL, Sun LY, Younus M, Ma SX, Liu C, Shi L, Lu Y, Zhou B, Sun SH, Chen GQ, Li J, Zhang QF, Zhu FP, Wang CH, and Zhou Z. Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway. 2023. Nat Commun 14, 1568.
7. He LL, Zhang QF, Wang LC, Dai JX, Wang CH, Zheng LH, Zhou Z. Muscarinic inhibition of nicotinic transmission in rat sympathetic neurons and adrenal chromaffin cells. 2015. Philos Trans R Soc Lond B Biol Sci 370(1672).
8. Dou H, Wang C, Wu X, Yao L, Zhang X, Teng S, Xu H, Liu B, Wu Q, Zhang Q, Hu M, Wang Y, Wang L, Wu Y, Shang S, Kang X, Zheng L, Zhang J, Raoux M, Lang J, Li Q, Su J, Yu X, Chen L, Zhou Z. Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. 2015. Diabetologia 58(2):324-333.
9. Shang S, Wang C, Liu B, Wu Q, Zhang Q, Liu W, Zheng L, Xu H, Kang X, Zhang X, Wang Y, Zheng H, Wang S, Xiong W, Liu T, Zhou Z. Extracellular Ca2+ per se inhibits quantal size of catecholamine release in adrenal slice chromaffin cells. 2014. Cell Calcium 56(3):202-207.
10. Kuo ST, Wu QH, Liu B, Xie ZL, Wu X, Shang SJ, Zhang XY, Kang XJ, Liu LN, Zhu FP, Wang YS, Hu MQ, Xu HD, Zhou L, Liu B, Chai ZY, Zhang QF, Liu W, Teng SS, Wang CH, Guo N, Dou HQ, Zuo PL, Zheng LH, Zhang CX, Zhu DS, Wang L, Wang SR, Zhou Z. Importing, caring, breeding, genotyping, and phenotyping a genetic mouse in a Chinese University. 2014. J Mol Neurosci: MN 53(3):487-492.