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教师队伍

教员 研究技术系列 工程技术系列 学院办公室

办公地址：北京大学综合科研二号楼315室

电子邮箱：zhaijinglei@pku.edu.cn

翟晶磊

助理教授、研究员、博士生导师

北京大学未来技术学院，分子医学研究所

国家自然科学基金优秀青年项目获得者


个人简介

翟晶磊课题组主要从事人造子宫和胚胎模型研究。方向包括：（1）搭建人造子宫，支持哺乳动物胚胎体外长时程发育；结合创新生物成像技术，追踪胚胎细胞的发育调节过程。（2）基于干细胞构建类胚胎或类器官模型，探究发育调控关键事件和作用机理。（3）基于人工智能算法、生物信息、生物成像等构建数字胚胎，仿真胚胎发育过程，揭示进化发育核心调控机理。以第一作者或共同第一作者在Science，Nature，Cell，Developmental Cell，Advanced Science等期刊发表多篇论文。2024年获得北京市科技新星创新新星项目，入选MIT科技评审亚太区35岁以下科技创新35人。


教育背景

2016.09-2020.07   中国科学院大学，基础医学博士，师从王红梅研究员

2013.09-2016.07   中国人民解放军军事医学科学院，联合培养硕士，师从裴雪涛教授

2013.09-2016.07   广西医科大学，生理学硕士

2008.09-2013.07   长治医学院，临床医学学士


工作简历

2025.11-至今         北京大学未来技术学院，助理教授、研究员

2023.02-2025.11   中国科学院动物研究所，副研究员

2023.07-2025.11   北京干细胞与再生医学研究院，致一研究员

2020.08-2023.02   中国科学院动物研究所，博士后


代表性论文及论著

(#first author or co-first author; *correspondence author)

  1. Zhai JL#, Xu YH#, Wan HF#, Yan R#, Guo J#, Skory R#, Yan L, Wu XL, Sun FY, Chen G, Zhao WT, Yu KY, Li W*, Guo F*, Plachta N*, and Wang HM* (2023). Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture. Cell, 186, 2078-2091 e2018. (article, Cover story). https://www.ncbi.nlm.nih.gov/pubmed/37172562

  2. Zhai JL#, Guo J#, Wan HF#, Qi LQ#, Liu LZ#, Xiao ZY, Yan L, Schmitz D., Xu YH, Yu DN, Wu XL, Zhao WT, Yu KY, Jiang XX*, Guo F*, Wu J*, and Wang HM* (2022). Primate gastrulation and early organogenesis at single-cell resolution. Nature, 612, 732-738. (article) https://www.ncbi.nlm.nih.gov/pubmed/36517595

  3. Ma HX#, Zhai JL#, Wan HF#, Jiang XX#, Wang XX, Wang L, Xiang YL, He XC, Zhao ZA, Zhao B, Zheng P*, Li L* and Wang HM* (2019). In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science 366. (article) https://www.ncbi.nlm.nih.gov/pubmed/31672918

  4. Xu YH#, Zhai JL#, Wu H#, Wang HM* (2024). In vitro culture of cynomolgus monkey embryos from blastocyst to early organogenesis. Nat Protoc 25. (article) https://www.nature.com/articles/s41596-024-01025-8

  5. Wu Hao#, Zhai JL#, Wang HM* (2024). Unraveling the function of FGF signaling in human hypoblast specialization. Cell Stem Cell 31, 945-946. (comment) https://www.ncbi.nlm.nih.gov/pubmed/38971145

  6. Wu XL#, Zhai JL#, Li Q#, Wang H* (2023). The in vitro culture of mammalian embryos. Nat Methods, 20, 1855-1858. (comment) https://www.ncbi.nlm.nih.gov/pubmed/38057510

  7. Jiang XX#, Zhai JL#, Xiao ZY#, Wu XL#, Zhang D#, Wan HF, Xu YH, Qi LQ, Wang MJ, Yu DN, Liu YW, Wu H, Sun R, Xia S, Yu KY, Guo JT, and Wang HM*. (2023). Identifying a dynamic transcriptomic landscape of the cynomolgus macaque placenta during pregnancy at single-cell resolution. Dev Cell. 9, 806-821 e7. （resource article） https://www.ncbi.nlm.nih.gov/pubmed/37054708

  8. Wang C#, Zhao B#, Zhai JL#, Wang AL#, Cao N, Liao TL, Su RY, He LJ, Li YH, Pei XT*, Yue W*, Jia YL* (2023). Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice. Cell Death Dis 14, 321. (article) https://www.ncbi.nlm.nih.gov/pubmed/37173309

  9. Zhai JL#, Xiao ZY#, Wang YM#, Wang HM* (2022). Human embryonic development: from peri-implantation to gastrulation. Trends Cell Biol 32, 18-29. (invited review). https://www.ncbi.nlm.nih.gov/pubmed/34417090

  10. Gu Z#, Guo J#, Zhai JL#, Feng GH#, Wang XN, Gao ZL, Li K, Ji S, Wang LY, Xu YH, Chen X, Wang YM, Guo SS, Yang M, Li LL, Han H, Jiang LY, Wen YQ, Wang L, Hao J, Li W, Wang ST*, Wang HM* and Gu Q*, (2022). A Uterus-Inspired Niche Drives Blastocyst Development to the Early Organogenesis. Adv Sci (Weinh), e2202282. (article) https://www.ncbi.nlm.nih.gov/pubmed/35843885

  11. Guo Z#, Zhao W#, Wang HM, Zhai JL* (2025). Recent insights into the culture systems for mammalian embryos. Curr Opin Genet Dev 91. https://pubmed.ncbi.nlm.nih.gov/39827579

  12. 于坤元#，刘子琛#，翟晶磊*（2025）哺乳动物胚胎体外培养研究进展。中国科学·生命科学https://doi.org/10.1360/SSV-2024-0159

  13. Yu DN#, Wan HF#, Tong C#, Guang L#, Chen G#, Su JL, Zhang L, Wang Y, Xiao ZY, Zhai JL, Yan L, Ma WW, Liang K, Liu TY, Wang YF, Peng ZH, Luo LF, Yu RX, Li W*, Qi HB*, Wang HM*, and Shyh-Chang N* (2024). A multi-tissue metabolome atlas of primate pregnancy. Cell, 187, 764-781 e714. (resource article) https://www.ncbi.nlm.nih.gov/pubmed/38306985

  14. Wu XL#, Zhao WT#, Wu H#, Zhang QC#, Wang YM, Yu KY, Zhai JL, Mo F, Wang MJ, Li SW, Zhu XL, Liang XY, Hu BY, Liu GH, Wu J, Wang HM, Guo F*, Yu LQ*. (2023). An aggregation of human embryonic and trophoblast stem cells reveals the role of trophectoderm on epiblast differentiation. Cell Prolif 56, e13492. (article) https://www.ncbi.nlm.nih.gov/pubmed/37199067

  15. Yan R#, Cheng X#, Gu C#, Xu YH, Long X, Zhai JL, Sun FY, Qian JJ, Du YR, Wang HM*, and Guo F*. (2023). Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development. Nat Genet 55, 130-143. (article) https://www.ncbi.nlm.nih.gov/pubmed/36539615

  16. Jia YL*, Cao N, Zhai JL, Zeng Q, Zheng P, Su RY, Liao TL, Liu JJ, Pei HY, Fan Z, Yue W*, Pei XT*. (2020). HGF Mediates Clinical-Grade Human Umbilical Cord-Derived Mesenchymal Stem Cells Improved Functional Recovery in a Senescence-Accelerated Mouse Model of Alzheimer's Disease. Adv Sci (Weinh) 7, 1903809. (article) https://www.ncbi.nlm.nih.gov/pubmed/32995116

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