首页 - 教师队伍 - 教员 - 分子医学研究所

教师队伍

办公地址:英杰交流中心337E

联系电话:010-62753212

电子邮箱:zzhou@pku.edu.cn

周专

教授

生物物理与退行性疾病研究室主任

国家杰出青年基金获得者


个人简介

荣获国家“杰出青年基金”、中科院“百人计划”、 全国优秀博士论文指导老师、美国“李氏基金奖”、教育部“高等学校科学研究优秀成果自然科学奖”一等奖。主要从事分泌的分子和细胞机制的研究。在Nature Neuroscience、Neuron、PNAS、Nature Communications等期刊上发表论文100余篇,。曾任中国生物物理学会副理事长兼神经生物物理专委会主任;担任《Journal of Physiology-London》、《Cell Calcium》、《Synapse》等国际专业期刊编委。


所授课程

本科生:

《整合实验课》(选修,3学分)

研究生:

《高级生物物理学》(必修,3学分)

《分子医学高级教程》(必修,3学分)

《神经分泌功能和机理研究进展》(选修,3学分)


主持研究生课程:

《高级生物学英文论文写作》(选修,1学分)


教育背景

1979-1984 上海, 同济大学电子仪器专业,学士学位。

1986-1990 武汉, 华中科技大学生物医学工程, 博士学位。


工作简历

1990.11-1993.2 德国, 马普生物物理化学研究所Erwin Neher教授实验室博士后

1992.3-1992.9 马普生物物理化学所Athur Konnerth实验室客座研究

1993.1-1993.6 马普医学研究所Bert Sakmann实验室客座研究

1993.2-1995.11 美国圣路易斯, 华盛顿大学生理和医学系讲师

1995.11-1997.8 美国芝加哥, Loyola大学生理系研究助理教授

1993.4-2000.5. 武汉, 华中理工大学, 生物物理与化学研究所,副教授(1993),教授(1995), 97.9- 99.10 合肥, 中国科技大学, 神经与生物物理系常务副主任, 教授。

1999.10-2004.12 上海,中国科学院神经科学研究所,细胞生物物理研究室主任,研究员

2005.1-至今 北京,北京大学分子医学研究所,高级研究员, 教授


承担项目

n 国家自然科学基金重点项目(课题负责人,项目编号31930061,“神经元离子通道-动作电位-量子化分泌关系研究”,303万,2020.01-2024.12)

n 国家自然科学基金重大项目(课题负责人,项目编号21790394,“帕金森综合症相关分子机制的研究与探索”,420万, 2018.01-2022.12)

n 科技部重点研发专项(项目编号:2016YFA0500400)“信使和能量物质跨膜转运的分子机器”,3455万元, 2016.8-2021.8,参与(本人负责300万元)

n 国家自然科学基金委国际(地区)合作与交流项目(课题负责人,项目编号,31761133016,解码帕金森病小鼠脑功能表型的创新“1+3”方法研究:MRI脑内微电极/光纤精准定位及光遗传刺激 + 同步钙信号,多巴胺信号, fMRI神经-代谢频谱信号记录“,180万,2018.01 - 2020.12,已结题)


代表性论文

1. Wang L, Gao M, Wang Q, Sun L, Younus M, Ma S, Liu C, Shi L, Lu Y, Zhou B, Sun S, Chen G, Li J, Zhang Q, Zhu F, Wang C, Zhou Z. Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice.  Nature Communications, 2023,14(1):1568. doi: 10.1038/s41467-023-37045-3..  

2. Wang Y, Huang R, Chai Z, Wang C, Du X, Hang Y, Xu Y, Li J, Jiang X, Wu X, Qiao Z, Li Y, Liu B, Zhang X, Cao P, Zhu F, Zhou Z. Ca2+ -independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons. EMBO Reports, 2022,23(11): e54507. doi: 10.15252/embr.202154507 .  

3. Lin Z, Li Y, Hang Y, Wang C, Liu B, Li J, Yin L, Jiang X, Du X, Qiao Z, Zhu F, Zhang Z, Zhang Q, Zhou Z. Tuning the Size of Large Dense-Core Vesicles and Quantal Neurotransmitter Release via Secretogranin II Liquid-Liquid Phase Separation. Advanced Science, 2022,9(27): e2202263. doi: 10.1002/advs.202202263.  

4. Zhu F, Liu L, Li J, Liu B, Wang Q, Jiao R, Xu Y, Wang L, Sun S, Sun X, Younus M, Wang C, Hokfelt T, Zhang B, Gu H, Xu ZD, Zhou Z  Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons. Cell Reports, 2022,40(7):111199. doi: 10.1016/j.celrep.2022.111199.  

5. Quanfeng Zhang , Bin Liu , Qihui Wu, Bing Liu , Yinglin Li , Suhua Sun, Yuan Wang, Xi Wu, Zuying Chai, Xiaohan Jiang, Xiaoyao Liu, Meiqin Hu, Yeshi Wang, Yunting Yang, Li Wang, Xinjiang Kang, Yingfei Xiong, Yang Zhou, Xiaoke Chen, Lianghong Zheng, Bo Zhang, Changhe Wang, Feipeng Zhu, Zhuan Zhou*, “Differential co-release of two neurotransmitters from a vesicle fusion pore in mammalian adrenal chromaffin cells.” Neuron,102(1):173-183 (2019).

6. Quanfeng Zhang, Bing Liu, Yinglin Li, Lili Yin, Muhammad Younus, Xiaohan Jiang, Zhaohan Lin, Xiaoxuan Sun, Rong Huang, Bin Liu, Qihui Wu, Feipeng Zhu, Zhuan Zhou*,“Regulating quantal size of neurotransmitter release through a GPCR voltage sensor.” Proc Natl Acad Sci U S A, 2020,117(43):26985-26995.

7. Mingli Li, Huadong Xu, Guoqing Chen, Suhua Sun, Qinglong Wang, Bing Liu, Xi Wu, Li Zhou, Zuying Chai, Xiaoxuan Sun, Yang Lu, Muhammad Younus, Lianghong Zheng, Feipeng Zhu, Hongbo Jia, Xiaowei Chen, Changhe Wang, Zhuan Zhou*,“Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson's disease.” Brain, 2019,142(10):3099-3115.

8. Rong Huang, Yuan Wang, Jie Li, Xiaohan Jiang, Yinglin Li, Bing Liu, Xi Wu, Xingyu Du, Yuqi Hang, Mu Jin, Feipeng Zhu, Changhe Wang*, Zuying Chai*, Zhuan Zhou*,“Ca 2+-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian sympathetic nervous system.”Proc Natl Acad Sci U S A, 2019,116(40):20201-20209.

10. Changhe Wang, Xinjiang Kang, Li Zhou, Zuying Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Suhua Sun, Jie Li, Ruiying Jiao, Panli Zuo, Lianghong Zheng, Zhenyu Yue, Zhuan Zhou*,“Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.” Nature Communications, 2018,9(1):81.

11. Zuying Chai, Changhe Wang, Rong Huang, Yuan Wang, Xiaoyu Zhang, Qihui Wu, Yeshi Wang, Xi Wu, Lianghong Zheng, Chen Zhang, Wei Guo, Wei Xiong, Jiuping Ding, Feipeng Zhu, Zhuan Zhou*,“CaV2.2 Gates Calcium-Independent but Voltage-Dependent Secretion in Mammalian Sensory Neurons.” Neuron, 2017,96(6):1317-1326.

12. Li Wang, Shujiang Shang, Xinjiang Kang, Sasa Teng, Feipeng Zhu, Bin Liu, Qihui Wu, Mingli Li, Wei Liu, Huadong Xu, Li Zhou, Ruiying Jiao, Haiqiang Dou 2, Panli Zuo, Xiaoyu Zhang, Lianghong Zheng, Shirong Wang, Changhe Wang, Zhuan Zhou*,“Modulation of dopamine release in the striatum by physiologically relevant levels of nicotine.” Nature Communications, 2014,5:3925.

13. Xiao-Ke Chen, Lie-Cheng Wang, Yang Zhou, Qian Cai, Murali Prakriya, Kai-Lai Duan, Zu-Hang Sheng, Christopher Lingle, Zhuan Zhou*,“Activation of GPCRs modulates quantal size in chromaffin cells through G(betagamma) and PKC.” Nature Neuroscience, 2005,8(9):1160-1168.

14. Zhang C & Zhou Z*, “Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons.”  Nature Neuroscience, 5(5):425-30(2002).

15. Chen Zhan g, Wei Xiong, Hui Zheng, Liecheng Wang, Bai Lu, Zhuan Zhou*,“Calcium- and dynamin-independent endocytosis in dorsal root ganglion neurons.” Neuron, 2004,42(2): 225-36.

16. Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, Fan Meng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Steven F. Dowdy, Neal K. Devaraj, Zhuan Zhou, William C. Mobley, Don W. Cleveland & Xiang-Dong Fu, Rversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature, 2020,582(7813):550-556. doi: 10.1038/s41586-020-2388-4. (my lab contribute the in vivo recordings of dopamine release in PD vs. WT mice. Fig. 5f-k)





TOP