教授
未来技术学院副院长
HHMI国际研究学者、科学探索奖获得者、国家杰出青年基金获得者
个人简介
刘颖教授从事细胞应激和稳态调控的研究，主要关注于细胞对线粒体胁迫和氨基酸匮乏的感知和响应机制。这些过程的失衡与癌症和代谢疾病密切相关，也是衰老的重要诱因。现为北大-清华生命科学联合中心、北京市未来基因诊断高精尖创新中心研究员，美国霍华德休斯医学研究所(HHMI)国际研究学者。入选国家杰青、“万人计划”科技创新领军人才，获科学探索奖、中国青年女科学家奖等。
教育背景
2002-2006 南京大学生物技术 学士
2006-2011美国得克萨斯大学西南医学中心 生物化学 博士
工作简历
2011.8 – 2014.2 美国麻省总医院、哈佛大学医学院博士后
2013.12 –2019.8 北京大学分子医学研究所 研究员
2019.8 –2021.2 北京大学分子医学研究所副所长、长聘副教授
2021.2–至今 北京大学未来技术学院副院长、教授
代表性论文
1. Wang D#, Xu C#, Yang W, Chen J, Ou Y, Guan Y, Guan J, Liu Y*; E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression, Molecular Cell 82 (2022) 709-712.
2. Xia P, Zhou L, Guan J, Ding W, Liu Y*; Splicing factor PRP-19 regulates mitochondrial stress response. Life Metabolism (2022) doi.org/10.1093/lifemeta/loac009.
3. Chen J#*, Ou Y#, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen P, Liu Y*. SAR1B senses leucine levels to regulate mTORC1 signalling. Nature (2021) 596(7871):281-284.
4. Li Y, Ding W, Li C-Y and Liu Y*. HLH-11 modulates lipid metabolism in response to nutrient availability. Nature Communications (2020) 11:5959.
5. Liu Y*. Epigenetic codes of mitochondrial homeostasis. Nature Aging 1 (2021) 153-154.
6. Shao L-W#, Peng Q#, Dong M, Gao K, Li YM, Li Y, Li C-Y* and Liu Y*. Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity. Nature Communications (2020) 11(1):4639.
7. Gao K, Li Y, Hu SM and Liu Y*. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. eLife (2019) e41792.
8. Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A and Liu Y*. N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation. Nature Cell Biology (2019) 21(3):319-327.
9. Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y and Liu Y*. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Nature 557(2018) 585-589.
10. Chen J#, Ou Y#, Li Y, Hu S, Shao LW and Liu Y*. Metformin extends C. elegans lifespan through lysosomal pathway. eLife 6 (2017) e31268.
11. Shao LW, Niu R and Liu Y*. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Res. 11 (2016) 1182-1196. (cover story)
12. Liu Y, Samuel BS, Breen PC and Ruvkun G. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature (2014) doi:10.1038/nature13204.
13. Liu Y, Tan H, Tian H, Liang C, Chen S and Liu Q. Autoantigen La promotes efficient RNAi, antiviral response and transposon silencing by facilitating multiple-turnover RISC catalysis. Mol. Cell 44 (2011) 502-508.
14. Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch L, Grishin N, Liu Q. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 5941 (2009) 750-753.