教授
个人简介
李川昀，1982年生。北京大学未来技术学院PI。2009年获北京大学博士学位，2011年在北京大学建立独立实验室。课题组以恒河猴为特色模型，探究人脑特异发育的分子基础。研究以多组学数据挖掘、机器学习算法开发与解析、新模型建立与机制发现为主线，解决了恒河猴研究的多个技术瓶颈，为运用其人类近缘特色开展精准的演化与机制研究奠定了基础。据此，准确鉴定人类特有新基因、新调控，提出新模型探究其起源与演化规律，并通过开展多层次实验研究，阐明多例新基因、新调控促进人脑增大、提升认知功能的新机制。以通讯作者在Nature Ecology & Evolution、Science Advances、PNAS、Genome Biology等发表论文21篇。Science等发表专评赞赏工作的创新性，新模型得到同行广泛认同。获“万人计划”青年拔尖人才（2014）、基金委优秀青年科学基金（2015）等支持，获贝时璋青年生物物理学家奖，指导博士生获吴瑞奖。
所授课程
本科生/研究生：
《基因组医学基础》（选修，2学分，获北京大学教学优秀奖）
《高级基因组医学》（选修，3学分）
教育背景
1999-2003 北京理工大学生命科学学院 本科
2007.9 – 2008.10 美国国立医学研究中心（NIH）交换学生 导师：George Uhl
2004.9-2009.2 北京大学生命科学学院 博士 导师：魏丽萍
工作简历
2009.3 –2010.12 北京大学生命科学学院 博士后
2011.1 –2019.7 北京大学分子医学研究所 研究员
2019.8 –现在 北京大学未来技术学院分子医学研究所 教授
承担项目
n 北京脑科学与类脑研究中心科研合作项目，人类特有调控在人脑发育中的功能探究，2021/01-2023/12
n 国家重点研发计划，2019YFA0801800，远程器官与骨髓的代谢特征及对话基础，2019/12-2024/11，
n 国家重点研发计划，2018YFA0801405，发育、代谢复杂疾病灵长类动物模型的创制与临床前研究，2019/11-2024/10
n 国家自然科学基金，31871272，基于全长转录谱的人类、恒河猴比较基因组学研究，2019/01-2022/12
代表性论文
1. Wanqiu Ding, Xiangshang Li, Jie Zhang, Mingjun Ji, Mengling Zhang, Xiaoming Zhong, Yong Cao, Chunqiong Li, Xiaoge Liu, Chunfu Xiao, Ting Li, Qing Yu, Fan Mo, Boya Zhang, Jianhuan Qi, Jie-Chun Yang, Jiaxin Wang, Juntian Qi, Lu Tian, Xinwei Xu, Qi Peng, Wei-Zhen Zhou, Zhijin Liu, Aisi Fu, Ni A. An, Xiuqing Zhang, Jian-Jun Zhang, Baoyang Hu, Yujie Sun, Li Zhang# and Chuan-Yun Li#, Adaptive Structural Variants Encode Human Uniqueness in Brain Developments, Science Advances, 2024
2. Xiaoge Liu, Chunfu Xiao, Xinwei Xu, Jie Zhang, Fan Mo, Jia-Yu Chen, Nicholas Delihas#, Li Zhang#, Ni A. An# and Chuan-Yun Li#, Origin of Functional De Novo Genes in Humans from “Hopeful Monsters”, WIREs RNA, 2024
3. Jie Zhang, Qi Peng, Chengchuan Ma, Chunfu Xiao, Ting Li, Xiaoge Liu, Liankui Zhou, Wei-Zhen Zhou, Wanqiu Ding, Ni A. An, Ying Liu# and Chuan-Yun Li# 6mA-Sniper: Quantifying 6mA Sites in Eukaryotes at Single-Nucleotide Resolution, Science Advances, 2023
4. Xiangshang Li, Chunfu Xiao, Juntian Qi, Weizhen Xue, Xinwei Xu, Zelin Mu, Jie Zhang, Chuan-Yun Li# and Wanqiu Ding#, STellaris: a web server for accurate spatial mapping of single cells based on spatial transcriptomics data Nucleic Acids Research, 2023
5. Chengchuan Ma, Tingling Xue, Qi Peng, Jie Zhang, Jialiang Guan, Wanqiu Ding, Yi Li, Peixue Xia, Liankui Zhou, Tianyu Zhao, Sheng Wang, Li Quan, Chuan-Yun Li#, and Ying Liu#, N6-Deoxyadenine methyltransferase modulates C. elegans immunity via dichotomous mechanisms, Cell Research, 2023 (Featured by Cell Research)
6. Jianhuan Qi, Fan Mo, Ni A. An, Tingwei Mi, Jiaxin Wang, Jun-Tian Qi, Xiangshang Li, Boya Zhang, Longkuo Xia, Yingfei Lu, Gaoying Sun, Xinyue Wang, Chuan-Yun Li#, and Baoyang Hu#, A Human-specific De Novo Protein Promotes Cortical Expansion and Folding, Advanced Science, 2023
7. Ni A. An, Jie Zhang, Fan Mo, Xuke Luan, Qing Sunny Shen, Xiangshang Li, Chunqiong Li, Lu Tian, Boya Zhang, Juntian Qi, Mingjun Ji, Jianhuan Qi, Wei-Zhen Zhou, Wanqiu Ding, Li Zhang, Jia-Yu Chen, Shaokun Shu, Baoyang Hu# and Chuan-Yun Li#, Human-specific genes with an lncRNA origin encode unique human brain developmental functionality, Nature Ecology & Evolution, 2023 (Featured by Science, Nature Ecology & Evolution)
8. Yumei Li, Qing Sunny Shen, Qi Peng, Wanqiu Ding, Jie Zhang, Xiaoming Zhong, Ni A. An, Mingjun Ji, Wei-Zhen Zhou, Chuan-Yun Li#; Polyadenylation-related isoform switching in human evolution revealed by full-length transcript structure, Briefings in Bioinformatics, 2021, bbab157
9. Li-Wa Shao, Qi Peng, Mingyue Dong, Kaiyu Gao, Yumei Li, Yi Li, Chuan-Yun Li# and Ying Liu#, Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity, Nature Communications, 2020
10. Ni A. An, Wanqiu Ding, Xin-Zhuang Yang, Jiguang Peng, Bin Z. He, Qing Sunny Shen, Fujian Lu, Aibin He, Yong E. Zhang, Bertrand Chin-Ming Tan, Jia-Yu Chen# and Chuan-Yun Li#, Evolutionarily Significant A-to-I RNA Editing Events Originated through G-to-A Mutations in Primates, Genome Biology, 2019
11. Yumei Li, Shanshan Ai, Xianhong Yu, Chen Li, Xin Li, Yanzhu Yue, Yusheng Wei, Chuan-Yun Li# and Aibin He#, Replication-independent histone turnover underlines the epigenetic homeostasis in adult heart, Circulation Research, 2019 (Featured by Circulation Research)
12. Yumei Li, Chen Li, Shuxian Li, Qi Peng, Ni A. An, Aibin He# and Chuan-Yun Li#, Human Exonization through Differential Nucleosome Occupancy, PNAS, 2018
13. Yao Xiao, Can Wang, Jia-Yu Chen, Fujian Lu, Jue Wang, Ning Hou, Xiaomin Hu, Fanxin Zeng, Dongwei Ma, Xueting Sun, Yi Ding, Yan Zhang, Wen Zheng, Yuli Liu, Haibao Shang, Wenzhen Zhu, Chensheng Han, Yulin Zhang, Kunfu Ouyang, Liangyi Chen, Ju Chen, Rui-Ping Xiao, Chuan-Yun Li# and Xiuqin Zhang#, Deficiency of PRKD2 Triggers Hyperinsulinemia and Metabolic Disorders, Nature Communications, 2018
14. Shi-Jian Zhang, Chenqu Wang, Shouyu Yan, Aisi Fu, Xuke Luan, Yumei Li, Qing Sunny Shen, Xiaoming Zhong, Jia-Yu Chen, Xiangfeng Wang, Bertrand Chin-Ming Tan, Aibin He and Chuan-Yun Li#, Isoform Evolution in Primates Through Independent Combination of Alternative RNA Processing Events, Molecular Biology and Evolution, 2017 (Cover Story, Fast Track Story)
15. Lei Lei, Shou-Yu Yan, Ran Yang, Jia-Yu Chen, Yumei Li, Ye Bu, Nannan Chang, Qinchao Zhou, Xiaojun Zhu, Chuan-Yun Li#, Jing-Wei Xiong#, Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors, Nucleic Acids Research, 2016
16. Xiaoming Zhong, Jiguang Peng, Qing Sunny Shen, Jia-Yu Chen, Han Gao, Xuke Luan, Shouyu Yan, Xin Huang, Shi-Jian Zhang, Luying Xu, Xiuqin Zhang, Bertrand Tan and Chuan-Yun Li#, RhesusBase PopGateway: Genome-wide Population Genetics Atlas in Rhesus Macaque, Molecular Biology and Evolution, 2016 (Featured by Molecular Biology and Evolution)
17. Xin-Zhuang Yang, Jia-Yu Chen, Chu-Jun Liu, Jiguang Peng, Yin Rei Wee, Xiaorui Han, Chenqu Wang, Xiaoming Zhong, Qing Sunny Shen, Hsuan Liu, Huiqing Cao, Xiaowei Chen, Bertrand Chin-Ming Tan# and Chuan-Yun Li#, Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates, Molecular Biology and Evolution, 2015
18. Jia-Yu Chen, Qing Sunny Shen, Wei-Zhen Zhou, Jiguang Peng, Bin Z He, Yumei Li, Chu-Jun Liu, Xuke Luan, Wanqiu Ding, Shuxian Li, Chunyan Chen, Bertrand Chin-Ming Tan, Yong E Zhang, Aibin He# and Chuan-Yun Li#, Emergence, Retention and Selection: a Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates, PLoS Genetics, 2015 (Featured by Faculty of 1000)
19. Shi-Jian Zhang, Chu-Jun Liu, Peng Yu, Xiaoming Zhong, Jia-Yu Chen, Xin-Zhuang Yang, Jiguang Peng, Shouyu Yan, Chenqu Wang, Xiaotong Zhu, Jingwei Xiong, Yong E. Zhang, Bertrand Chin-Ming Tan and Chuan-Yun Li#, Evolutionary Interrogation of Human Biology in Well-annotated Genomic Framework of Rhesus Macaque, Molecular Biology and Evolution, 2014 (Cover Story, MBE Most Read)
20. Jia-Yu Chen, Zhiyu Peng, Rongli Zhang, Xin-Zhuang Yang, Bertrand Chin-Ming Tan, Huaying Fang, Chu-Jun Liu, Yong E. Zhang, Mingming Shi, Zhi-Qiang Ye, Minghua Deng, Xiuqin Zhang# and Chuan-Yun Li#, RNA Editome in Rhesus Macaque Shaped by Purifying Selection, PLoS Genetics, 2014
21. Shi-Jian Zhang, Chu-Jun Liu, M Shi, Lei Kong, Jia-Yu Chen, Wei-Zhen Zhou, Xiaotong Zhu, Peng Yu, Jue Wang, Xinzhuan Yang, Ning Hou, Zhiqiang Ye, Rongli Zhang, Ruiping Xiao, Xiuqin Zhang# and Chuan-Yun Li#, RhesusBase: a Knowledgebase for the Monkey Research Community. Nucleic Acids Research, 2013 (Featured by Nucleic Acids Research and Biomart)
22. Chen Xie, Yong E. Zhang, Jia-Yu Chen, Chu-Jun Liu, Wei-Zhen Zhou, Ying Li, Mao Zhang, Rongli Zhang, Liping Wei# and Chuan-Yun Li#, Hominoid-specific De Novo Protein-coding Genes Originating from Long Non-coding RNAs, PLoS Genetics, 2012 (Featured by Faculty of 1000)
23. Chuan-Yun Li#, Wei-Zhen Zhou, Ping-Wu Zhang, Catherine Johnson, Liping Wei, George R Uhl#, Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction, BMC Genomics, 2011 (Highly accessed article)
24. Chuan-Yun Li, Yong Zhang, Zhanbo Wang, Yan Zhang, Chunmei Cao, Ping-Wu Zhang, Shu-Juan Lu, Xiao-Mo Li, Quan Yu, Xiaofeng Zheng, Quan Du, Qing-Rong Liu* and Liping Wei*, A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions, PLoS Computational Biology, 2010
25. Chuan-Yun Li, Xizeng Mao & Liping Wei, Genes and (Common) Pathways Underlying Drug Addiction, PLoS Computational Biology, 2008 (Featured by Science Signaling “Editor’s Choice”; Nature China “Research Highlights”; the Economist, Scientific America, Reuters and China Daily; Top 10 Papers downloaded from PLoS Computational Biology)
26. Chuan-Yun Li, Qingrong Liu, Ping-Wu Zhang, Xiao-Mo Li, Liping Wei, George R Uhl, OKCAM: An Ontology-based, Human-centered Knowledgebase for Cell Adhesion Molecules, Nucleic Acids Research, 2008
27. Chuan-Yun Li, Quan Yu, Zhi-Qiang Ye, Ying Sun, Quanyuan He, Xiao-Mo Li, Wuxue Zhang, Jingchu Luo, Xiaocheng Gu, Xiaofeng Zheng & Liping Wei, A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir, Cell Research, 2007 (Cover story and featured by a Research Highlight; Cited by US FDA annual Pediatric Safety Update for Tamiflu; Interviewed by NHK and CCTV)