研究员 博士生导师
生命科学联合中心研究员
个人简介
研究工作围绕“中心法则”，综合运用生物、化学、物理等多学科交叉，建立了空间翻译组、空间转录组与蛋白质共检测技术、时空转录组等空间单细胞测序技术，并且在时空水平探究基因表达调控。相关工作发表在 Science、Nature Neuroscience、Nature Methods等杂志，申请国际专利4项。实验室之后研究方向主要是开发新型空间单细胞多组学测序技术，并应用这些技术在分子层面探究神经退行性疾病和肿瘤等重大疾病的致病机理。
教育背景
2009 – 2013 中山大学生命科学学院 本科
2013 – 2019 北京大学生命科学学院 博士
工作简历
2020 - 2023 麻省理工学院与哈佛大学Broad研究所 博士后
2023 – 现在 北京大学未来技术学院 研究员 博士生导师
代表性论文及论著：
1. H Zeng#, J Huang#, J Ren#, C K Wang, Z Tang, H Zhou, Y Zhou, H Shi, A Aditham, X Sui, H Chen, J A Lo, X Wang*. Spatially Resolved single-cell translatomics at molecular resolution. Science (2023) 380, eadd3067. (Highlighted in the Nature Reviews Genetics and Nature Methods ).
2. J Ren#, H Zhou#, H Zeng#, C K Wang, J Huang, X Qiu, X Sui, Q Li, X Wu, Z Lin, J A Lo, K Maher, Y He, X Tang, J Lam, H Chen, B Li, D E Fisher, J Liu, X Wang*. Spatiotemporally resolved transcriptomics reveals the subcellular RNA kinetic landscape. Nat. Methods (2023) 20, 695–705.
3. H Zeng#, J Huang#, H Zhou#, W J. Meilandt, B Dejanovic, Y Zhou, C J. Bohlen, S Lee, J Ren, A Liu, Z Tang, H Sheng, J Liu, M Sheng*, X Wang*. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease. Nat. Neurosci. (2023) 26, 430–446.
4. B He#, C Zhang#, X Zhang#, Y Fan#, H Zeng, J Liu, H Meng, D Bai, J Peng, Q Zhang*, W Tao*, C Yi*. Tissue-specific 5-hydroxymethylcytosine landscape of the human genome. Nat. Commun. (2021) 12:4249.
5. M Liu#, J Zhang#, C Zhu#, X Zhang, W Xiao, Y Yan, L Liu, H Zeng, YQ Gao*, C Yi*. DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat. Commun. (2021) 12:4108.
6. A Aditham#, H Shi#, J Guo, H Zeng, Y Zhou, S D Wade, J Huang, J Liu, X Wang*. Chemically modified mocRNAs for highly efficient protein expression in mammalian cells. ACS Chem. Biol. (2022) 17, 3352-3366.
7. H Zeng#, M Mondal#, R Song#, J Zhang, B Xia, M Liu, C Zhu, B He, YQ Gao* and C Yi*. Unnatural cytosine bases recognized as thymines by DNA polymerases via the formation of the Watson-Crick geometry. Angew. Chem. Int. Ed. (2019) 58, 130-133.
8. H Zeng#, B He#, C Yi*. Compilation of modern technologies to map genome-wide cytosine modifications in DNA. Chembiochem (2019) 20, 1898-1905.(Review)
9. H Zeng#, B He#, B Xia, D Bai, X Lu, J Cai, L Chen, A Zhou, C Zhu, H Meng, Y Gao, H Guo, C He*, Q Dai*, and C Yi*. Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution. J. Am. Chem. Soc. (2018) 140, 13190-13194.
10. H Zeng#, B He#, C Yi*, and J Peng*. Liquid biopsies: DNA methylation analyses in circulating cell-free DNA. J. Genet. Genomics (2018) 45, 185-192. (Review)
11. C Zhu#, Y Gao#, H Guo#, B Xia#, J Song, X Wu, H Zeng, K Kee, F Tang*, and C Yi*. Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution. Cell Stem Cell (2017) 20, 720-731 e725.
12. B Xia#, D Han#, X Lu#, Z Sun, A Zhou, Q Yin, H Zeng, M Liu, X Jiang, W Xie, C He*, and C Yi*. Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale. Nat. Methods (2015) 12, 1047-1050.